Assessment of Triglyceride-Glucose Index and Ratio in Patients with Type 2 Diabetes and Their Relation to Microvascular Complications.

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine Research Pub Date : 2023-10-02 Epub Date: 2023-08-11 DOI:10.1080/07435800.2023.2245909

Heba S Kassab, Nermin A Osman, Shimaa M Elrahmany

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Abstract

Objective: Triglyceride-based indices have gained much attention over the past few years. Relation of triglyceride - glucose (TyG) index with insulin resistance and diabetic macrovascular complications was thoroughly studied; nevertheless its relation to microvascular complications is still unclear. This provoked us to carry out the present study.

Methods: This cross-sectional study included 500 patients with type 2 diabetes (T2DM), who were enrolled from the outpatient clinic of the Diabetes and Metabolism Unit at Alexandria Main University Hospital. The equations utilized to calculate triglycerides-related indices were: TyG ratio = fasting triglycerides (mg/dL)/fasting glucose (mg/dL), and TyG index = logarithm of [fasting triglyceride (mg/dl) x fasting glucose (mg/dl)/2]. The diagnostic criteria set by the American Diabetes Association were followed to diagnose diabetic microvascular complications.

Results: In patients with T2DM, TyG index was significantly higher in patients with diabetic retinopathy, diabetic kidney disease, and diabetic peripheral neuropathy compared to those without complications (p < 0.001). TyG index was significantly positively correlated to diabetes duration, as well as triglyceride/high density lipoprotein ratio in the total sample (p < 0.001).

Conclusion: TyG index is an easy, cheap, and available marker for detection of microvascular complications in patients with T2DM.

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2型糖尿病患者甘油三酯-葡萄糖指数和比值的评估及其与微血管并发症的关系。

目的：基于甘油三酯的指标在过去几年中受到了广泛关注。深入研究了甘油三酯-葡萄糖（TyG）指数与胰岛素抵抗和糖尿病大血管并发症的关系；然而，它与微血管并发症的关系尚不清楚。这促使我们进行本研究。方法：这项横断面研究包括500名2型糖尿病（T2DM）患者，他们来自亚历山大美茵大学医院糖尿病和代谢科的门诊。用于计算甘油三酯相关指数的方程式为：TyG比率 = 空腹甘油三酯（mg/dL）/空腹血糖（mg/dL）和TyG指数 = [空腹甘油三酯（mg/dl）x空腹血糖（mg/dl 2]的对数。遵循美国糖尿病协会制定的诊断标准来诊断糖尿病微血管并发症。结果：在T2DM患者中，糖尿病视网膜病变、糖尿病肾病和糖尿病周围神经病变患者的TyG指数明显高于无并发症患者（p p 结论：TyG指数是一种简便、廉价、有效的检测T2DM患者微血管并发症的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.

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