Adverse Drug Reactions to Antiretroviral Therapy: Frequency, Type, and Risk Factors in Children in Mali.

Aboubacar Alassane Oumar, Alassane Seydou, Souleymane Fofana, Zoumana Diarra, Djeneba Mariko, Abdallah Diallo, Sanata Coulibaly, Lala N Sidibe, Boubacar Togo, Sounkalo Dao, Seydou Doumbia, Paul M Tulkens
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引用次数: 1

Abstract

Objective: The aim of our study was to evaluate the frequency, type, and risk factors associated with adverse drug reactions (ADRs) in HIV-positive children with adherence to antiretroviral therapy (ART) at the Unit of Care and Accompaniment for People Living With HIV (USAC) of Bamako.

Methods: A cross-sectional study was conducted at USAC of Bamako from May 1, 2014, to July 31, 2015. We included children aged 1 to 14 years with at least 6 months of ARV treatment initiated at USAC, with or without ADRs. Data collection was based on information collected from parents and clinical/biological assessments.

Results: Median age of participants was 36 months and female sex was predominant (54.8%). Poor adherence during the study was observed in 15% of cases. Of patients in the study, 52% had a CD4 count less than 350 cells/mm3 at the time of adverse events. In bivariate analysis, we found that participants with adherence to ART tended to be younger than those with non-adherence to ART (36 vs 72 months, p = 0.093). In multivariable analysis, prophylactic treatment was the only factor marginally associated with ART adherence in HIV patients (p = 0.09). No other adverse biological effects or clinical conditions were associated with ART adherence in this study.

Conclusions: In this study we found that ADRs were frequent in HIV-positive patients but less frequent in ART-adherent HIV-positive children. Therefore, it is essential to regularly monitor children receiving ARVs to detect and treat the complications associated with these therapies according to ART adherence.

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抗逆转录病毒治疗的药物不良反应:马里儿童的频率、类型和危险因素。
目的:本研究的目的是评估巴马科艾滋病毒感染者护理和陪伴中心(USAC)坚持抗逆转录病毒治疗(ART)的艾滋病毒阳性儿童药物不良反应(adr)的频率、类型和相关危险因素。方法:2014年5月1日至2015年7月31日在巴马科USAC进行横断面研究。我们纳入了在USAC接受至少6个月ARV治疗的1至14岁儿童,不论有无不良反应。数据收集基于从家长处收集的信息和临床/生物学评估。结果:参与者年龄中位数为36个月,以女性为主(54.8%)。在研究期间,有15%的病例依从性差。在该研究中,52%的患者在不良事件发生时CD4计数低于350细胞/mm3。在双变量分析中,我们发现坚持ART治疗的患者往往比不坚持ART治疗的患者更年轻(36个月vs 72个月,p = 0.093)。在多变量分析中,预防性治疗是唯一与HIV患者抗逆转录病毒治疗依从性有轻微相关性的因素(p = 0.09)。在这项研究中,没有其他不良生物学效应或临床状况与抗逆转录病毒治疗依从性相关。结论:在本研究中,我们发现hiv阳性患者的不良反应发生率较高,而抗逆转录病毒治疗的hiv阳性儿童的不良反应发生率较低。因此,必须定期监测接受抗逆转录病毒药物治疗的儿童,以根据抗逆转录病毒药物的依从性发现和治疗与这些疗法相关的并发症。
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来源期刊
Journal of Pediatric Pharmacology and Therapeutics
Journal of Pediatric Pharmacology and Therapeutics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
2.40
自引率
0.00%
发文量
90
期刊介绍: The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.
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