Changes in fatigue among cancer patients before, during, and after radiation therapy: A meta-analysis.

IF 3.4 2区医学 Q1 NURSING Worldviews on Evidence-Based Nursing Pub Date : 2024-06-01 Epub Date: 2023-08-13 DOI:10.1111/wvn.12672

Chia-Ling Li, Pei-Ying Chen, Tsui-Yun Yang, Joseph Tung-Chieh Chang, Woung-Ru Tang, Mei-Ling Chen

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Abstract

Background: Fatigue is a common symptom in cancer patients receiving radiotherapy. However, previous studies report inconsistent patterns of fatigue change.

Aim: The aim of this study was to estimate changes in fatigue among patients with cancer before, during, and after radiotherapy.

Methods: Five databases (PubMed, SDOL, CINAHL Plus with Full Text, Medline [ProQuest], and ProQuest Dissertations) were searched for studies published from January 2006 to May 2021. Three effect sizes of fatigue change (immediate, short-term, and long-term) were calculated for each primary study using standardized mean difference. A random-effect model was used to combine effect sizes across studies. Subgroup analyses and meta-regression were performed to identify potential categorical and continuous moderators, respectively.

Results: Sixty-five studies were included in this meta-analysis. The weighted mean effect size for immediate, short-term, and long-term effects was 0.409 (p < .001; 95% CI [0.280, 0.537]), 0.303 (p < .001; 95% CI [0.189, 0.417]), and 0.201 (p = .05; 95% CI [-0.001, 0.404]), respectively. Studies with prostate cancer patients had a significantly higher short-term (0.588) and long-term weight mean effect size (0.531) than studies with breast (0.128, -0.072) or other cancers (0.287, 0.215). Higher radiotherapy dosage was significantly associated with a higher effect size for both immediate (β = .0002, p < .05) and short-term (β = .0002, p < .05) effect.

Linking evidence to action: Findings from this meta-analysis indicated that radiotherapy-induced fatigue (RIF) exist for more than 3 months after the completion of treatment. Assessment of radiation-induced fatigue in cancer patients should extend long after treatment completion, especially for patients with prostate cancer and patients receiving a higher radiation dose. Interventions to reduce fatigue tailored for different treatment phases may be developed.

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癌症患者在放疗前、放疗中和放疗后的疲劳变化：荟萃分析

背景疲劳是接受放疗的癌症患者的常见症状。目的：本研究旨在估计癌症患者在放疗前、放疗期间和放疗后的疲劳变化：检索了五个数据库（PubMed、SDOL、CINAHL Plus with Full Text、Medline [ProQuest] 和 ProQuest Dissertations）中 2006 年 1 月至 2021 年 5 月期间发表的研究。使用标准化均值差计算了每项主要研究中疲劳变化的三个效应大小（即时、短期和长期）。采用随机效应模型合并各研究的效应大小。分别进行了分组分析和元回归，以确定潜在的分类调节因子和连续调节因子：本次荟萃分析共纳入 65 项研究。即时效应、短期效应和长期效应的加权平均效应大小为 0.409（p 将证据与行动联系起来：这项荟萃分析的结果表明，放疗引起的疲劳（RIF）在治疗结束后的三个月内都会存在。对癌症患者放疗所致疲劳的评估应在治疗结束后的较长时间内进行，尤其是前列腺癌患者和接受较高放射剂量的患者。可针对不同的治疗阶段制定减少疲劳的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Worldviews on Evidence-Based Nursing 医学-护理

CiteScore

6.10

自引率

11.60%

发文量

审稿时长

>12 weeks

期刊介绍： The leading nursing society that has brought you the Journal of Nursing Scholarship is pleased to bring you Worldviews on Evidence-Based Nursing. Now publishing 6 issues per year, this peer-reviewed journal and top information resource from The Honor Society of Nursing, Sigma Theta Tau International, uniquely bridges knowledge and application, taking a global approach in its presentation of research, policy and practice, education and management, and its link to action in real world settings. Worldviews on Evidence-Based Nursing is written especially for: Clinicians Researchers Nurse leaders Managers Administrators Educators Policymakers Worldviews on Evidence-Based Nursing is a primary source of information for using evidence-based nursing practice to improve patient care by featuring: Knowledge synthesis articles with best practice applications and recommendations for linking evidence to action in real world practice, administra-tive, education and policy settings Original articles and features that present large-scale studies, which challenge and develop the knowledge base about evidence-based practice in nursing and healthcare Special features and columns with information geared to readers’ diverse roles: clinical practice, education, research, policy and administration/leadership Commentaries about current evidence-based practice issues and developments A forum that encourages readers to engage in an ongoing dialogue on critical issues and questions in evidence-based nursing Reviews of the latest publications and resources on evidence-based nursing and healthcare News about professional organizations, conferences and other activities around the world related to evidence-based nursing Links to other global evidence-based nursing resources and organizations.