N6-methyladenosine (m6A) methylation in kidney diseases: Mechanisms and therapeutic potential

IF 2.6 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2023-08-06 DOI:10.1016/j.bbagrm.2023.194967

Yuting Sun , De Jin , Ziwei Zhang , Hangyu Ji , Xuedong An , Yuehong Zhang , Cunqing Yang , Wenjie Sun , Yuqing Zhang , Yingying Duan , Xiaomin Kang , Linlin Jiang , Xuefei Zhao , Fengmei Lian

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Abstract

The N6-methyladenosine (m6A) modification is regulated by methylases, commonly referred to as “writers,” and demethylases, known as “erasers,” leading to a dynamic and reversible process. Changes in m6A levels have been implicated in a wide range of cellular processes, including nuclear RNA export, mRNA metabolism, protein translation, and RNA splicing, establishing a strong correlation with various diseases. Both physiologically and pathologically, m6A methylation plays a critical role in the initiation and progression of kidney disease. The methylation of m6A may also facilitate the early diagnosis and treatment of kidney diseases, according to accumulating research. This review aims to provide a comprehensive overview of the potential role and mechanism of m6A methylation in kidney diseases, as well as its potential application in the treatment of such diseases. There will be a thorough examination of m6A methylation mechanisms, paying particular attention to the interplay between m6A writers, m6A erasers, and m6A readers. Furthermore, this paper will elucidate the interplay between various kidney diseases and m6A methylation, summarize the expression patterns of m6A in pathological kidney tissues, and discuss the potential therapeutic benefits of targeting m6A in the context of kidney diseases.

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肾脏疾病中N6-甲基腺苷（m6A）甲基化的机制和治疗潜力

N6-甲基腺苷（m6A）修饰由甲基化酶（通常称为“写入器”）和去甲基化酶，称为“擦除器”调节，导致一个动态和可逆的过程。m6A水平的变化与广泛的细胞过程有关，包括核RNA输出、mRNA代谢、蛋白质翻译和RNA剪接，与各种疾病建立了强烈的相关性。在生理学和病理学上，m6A甲基化在肾脏疾病的发生和发展中起着关键作用。根据不断积累的研究，m6A的甲基化也可能有助于肾脏疾病的早期诊断和治疗。这篇综述旨在全面综述m6A甲基化在肾脏疾病中的潜在作用和机制，以及它在治疗此类疾病中的可能应用。将对m6A甲基化机制进行彻底检查，特别注意m6A写入器、m6A擦除器和m6A读取器之间的相互作用。此外，本文将阐明各种肾脏疾病与m6A甲基化之间的相互作用，总结病理性肾脏组织中m6A的表达模式，并讨论靶向m6A在肾脏疾病中的潜在治疗益处。

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来源期刊

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

44 days

期刊介绍： BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.