Changing trends in the epidemiology of gastric cancer.

Q2 Medicine Medicine and Pharmacy Reports Pub Date : 2023-07-01 DOI:10.15386/mpr-2538

Cosmin Grad, Simona Grad, Radu A Fărcaş, Stefan Popa, Dan L Dumitraşcu

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Abstract

Currently being the seventh most prevalent form of cancer worldwide, and the fifth most common cause of cancer-related death, based on GLOBOCAN 2020 data, gastric cancer is still an important public health problem, despite its dropping incidence. Regions around the world are still at high-risk, mostly in populations with a high prevalence of Helicobacter pylori infection or a carcinogenic favorable diet. Gastric cardia cancer incidence is on the rise in some areas. Great steps were made in the last decades in understanding the pathogenesis of gastric cancer and its risk factors. Host genetic polymorphisms play a quintessential role in disease outcome. Helicobacter pylori eradication and endoscopic surveillance are the most effective options to further decrease gastric cancer incidence. Surgery is required for a curative treatment in most cases. This review summarizes the latest worldwide epidemiological data of gastric cancer and aims to provide an accessible and credible source of evidence for physicians who assess risk factors for gastric cancer.

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胃癌流行病学的变化趋势。

根据GLOBOCAN 2020的数据，目前胃癌是全球第七大最常见的癌症形式，也是癌症相关死亡的第五大常见原因，尽管发病率有所下降，但它仍然是一个重要的公共卫生问题。世界各地的地区仍处于高风险，主要是在幽门螺杆菌感染高发或有利致癌饮食的人群中。贲门癌的发病率在一些地区呈上升趋势。近几十年来，在了解胃癌的发病机制及其危险因素方面取得了重大进展。宿主遗传多态性在疾病结果中起着典型的作用。根除幽门螺杆菌和内镜监测是进一步降低胃癌发病率的最有效选择。在大多数情况下，治愈性治疗需要手术。本文综述了世界范围内最新的胃癌流行病学数据，旨在为医生评估胃癌危险因素提供一个可获取和可信的证据来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicine and Pharmacy Reports Medicine-Medicine (all)

CiteScore

3.10

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0.00%

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