间歇性禁食对2型糖尿病患者血糖控制的影响:随机对照试验的系统回顾和荟萃分析

Suresh K Sharma, Shiv Kumar Mudgal, Sanjay Kalra, Rakhi Gaur, Kalpana Thakur, Rajat Agarwal
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引用次数: 3

摘要

背景:2型糖尿病(T2DM)是严重的公共卫生问题,严重影响人类的生活和健康支出。文献中已经观察到,间歇性禁食(IF)可以解决糖尿病及其潜在原因,这对糖尿病患者有益。因此,本研究旨在评价IF治疗对T2DM患者血糖控制的效果,并与对照组进行比较。方法:对以糖化血红蛋白(HbA1c)为结局的T2DM患者的介入研究进行系统回顾和荟萃分析。对PubMed、Embase和Google Scholar等电子数据库进行全面检索,检索2022年4月24日之前发表的文章。报告24小时完全禁食或间歇性限制能量摄入(每天只允许进食4-8小时,禁食16-20小时)和报告HbA1c和空腹血糖水平变化的研究符合条件。采用Cochrane’s Q统计量和I2统计方法进行meta分析。结果:分析了11项研究(13组)测量IF对患者HbA1c水平的影响。IF组与对照组间差异无统计学意义(标准化平均差[SMD] -0.08, 95%可信区间[CI] -0.20 ~ 0.04;p=0.19, I2=22%)。总的来说,我们分析了7项关于患者空腹血糖的研究,meta分析显示两组即IF和对照组之间无显著差异(SMD为0.06,95% CI为-0.25 ~ 0.38;p=0.69, I2=76%)。结论:空腹饮食与常规饮食在血糖控制方面无显著差异。虽然,IF可以作为糖尿病前期人群的预防性饮食模式,因为它在长期控制血糖水平方面效果很好。研究注册:本研究的方案已在国际前瞻性系统评价登记册(PROSPERO)上注册,注册号为CRD42022328528。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Effect of Intermittent Fasting on Glycaemic Control in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Background: Type 2 diabetes mellitus (T2DM) is a severe public health issue notably impacting human life and health expenditure. It has been observed in literature that intermittent fasting (IF) addresses diabetes and its underlying cause, which benefits people with diabetes. Therefore, this study aimed to evaluate the effectiveness of IF treatment on glycaemic control in people with T2DM compared with control group. Methods: Systematic review and meta-analysis of interventional studies among patients with T2DM with glycated haemoglobin (HbA1c) as an outcome was performed. A comprehensive search of electronic databases, including PubMed, Embase and Google Scholar, for articles published before 24 April 2022, was done. Studies reporting 24 hours of complete fasting or intermittent restricted energy intake (feeding permitted for only 4-8 hours daily, with 16-20 hours of fasting) and reporting changes in HbA1c and fasting glucose levels were eligible. Meta-analysis was performed using Cochrane's Q statistic and the I2 statistical approach. Results: Eleven studies (13 arms) measuring the effect of IF on patients' HbA1c level were analysed. There was no statistically significant difference between IF and control groups (Standardized mean difference [SMD] -0.08, 95% confidence interval [CI] -0.20 to 0.04;p=0.19, I2=22%). Overall, seven studies on patients' fasting blood glucose were analysed, and the meta-analysis revealed no significant difference between the two groups i.e. IF and control groups (SMD 0.06, 95% CI -0.25 to 0.38;p=0.69, I2=76%). Conclusion: IF and usual diet pattern have no difference in terms of glycaemic control. Although, IF may be used as a preventative diet pattern in the pre-diabetic population, as it works well in the long-term to achieve controlled sugar levels. Study registration: The protocol of this study was registered in The International Prospective Register of Systematic Reviews (PROSPERO) with a registration number CRD42022328528.

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