血小板与淋巴细胞比率作为原发性高血压的间接预后预测因子:一项回顾性研究。

Rita Pinho, Rui Ribeiro, Diana Ferrão, Rui Medeiros, Maria João Lima, Jorge Almeida, Margarida Freitas-Silva
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摘要

背景:非北侧高血压患者具有更高水平的血小板与淋巴细胞比率,这是一种新的研究发现的原发性高血压炎症生物标志物。此外,这些患者患心血管疾病和死亡的风险更高。本研究旨在评估血小板/淋巴细胞比率与高血压模式(与非高血压模式)之间的关系,以及高血压模式与主要不良心血管事件之间的关系。方法:回顾性分析。纳入153例患者,根据24小时动态血压测量将其分为斗式和非斗式。血小板与淋巴细胞比值根据全血细胞计数数据计算。结果:使用勺组109例,不使用勺组44例。未使用蘸剂的患者出现血小板/淋巴细胞比率较高的风险比使用蘸剂的患者高2.11(优势比[OR] = 2.11;95% ci, 1.220-3.664;P = .007)。未使用水杯的患者也记录了更早的心血管事件,如急性心肌梗死和卒中(P < 0.001)。结论:非尿床高血压患者的血小板/淋巴细胞比率高于尿床患者,心血管事件发生更早。因此,血小板与淋巴细胞比率可以作为原发性高血压心血管风险的间接预测因子,并有助于优化预防策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The platelet-to-lymphocyte ratio as an indirect outcome predictor in primary hypertension: a retrospective study.

Background: Nondipper hypertensive patients have higher levels of platelet-to-lymphocyte ratio, a new studied inflammatory biomarker in primary hypertension. Furthermore, these patients have a higher risk of cardiovascular morbidity and mortality. This study aimed to assess the relationship between platelet-to-lymphocyte ratio and hypertensive pattern (dipper vs nondipper) and the association between the hypertensive pattern and major adverse cardiovascular events.

Methods: A retrospective analysis was performed. One hundred fifty-three patients were included and classified as dipper or nondipper according to 24-hour ambulatory blood pressure measurements. Platelet-to-lymphocyte ratio was calculated based on complete blood count data.

Results: The dipper group included 109 patients, and the nondipper group included 44 patients. Nondipper patients have 2.11 more risk of presenting a higher platelet-to-lymphocyte ratio than dipper individuals (odds ratio [OR] = 2.11; 95% CI, 1.220-3.664; P = .007). Nondipper patients also registered earlier cardiovascular events, such as acute myocardial infarction and stroke (P < .001).

Conclusions: Nondipper hypertensive individuals registered higher levels of platelet-to-lymphocyte ratio and earlier cardiovascular events than dipper patients. Therefore, platelet-to-lymphocyte ratio could be used as an indirect predictor of cardiovascular risk in primary hypertension and contribute to optimize preventive strategies.

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