GLIS2和CCND1在乳腺癌患者中的表达水平。

Breast disease Pub Date : 2023-01-01 DOI:10.3233/BD-220068

Minoosh Sadeghi, Majid Gholizadeh, Neda Safataj, Mahsa Tahmasebivand, Gholamreza Mohajeri, Hajie Lotfi, Saber Yari Bostanabad, Behnaz Safar, Mansoor Salehi

{"title":"GLIS2和CCND1在乳腺癌患者中的表达水平。","authors":"Minoosh Sadeghi, Majid Gholizadeh, Neda Safataj, Mahsa Tahmasebivand, Gholamreza Mohajeri, Hajie Lotfi, Saber Yari Bostanabad, Behnaz Safar, Mansoor Salehi","doi":"10.3233/BD-220068","DOIUrl":null,"url":null,"abstract":"Background: Breast cancer (BC) is the most prevalent cancer in women, with increasing incidence and death rates in recent years. Disruptions of different signaling pathways partially cause breast cancer. Hence, different genes through particular pathways are involved in BC tumorigenesis.Methods: In this study, we evaluated the expression level of GLIS2 and CCND1 genes in 50 patients. Also, in-silico analyses were used to enrich related signaling pathways involving the mentioned genes.Results: The results showed an increased expression level of Cyclin D1 and decreased expression level of GLIS2 in BC patients. Moreover, a relationship between aberrant expression levels of GLIS2 and CCND1 and BC development was determined.Conclusion: These observations could help uncover new therapeutic targets for treating patients with BC in the progressive stage.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"42 1","pages":"251-259"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"GLIS2 and CCND1 expression levels in breast cancer patients.\",\"authors\":\"Minoosh Sadeghi, Majid Gholizadeh, Neda Safataj, Mahsa Tahmasebivand, Gholamreza Mohajeri, Hajie Lotfi, Saber Yari Bostanabad, Behnaz Safar, Mansoor Salehi\",\"doi\":\"10.3233/BD-220068\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Breast cancer (BC) is the most prevalent cancer in women, with increasing incidence and death rates in recent years. Disruptions of different signaling pathways partially cause breast cancer. Hence, different genes through particular pathways are involved in BC tumorigenesis.Methods: In this study, we evaluated the expression level of GLIS2 and CCND1 genes in 50 patients. Also, in-silico analyses were used to enrich related signaling pathways involving the mentioned genes.Results: The results showed an increased expression level of Cyclin D1 and decreased expression level of GLIS2 in BC patients. Moreover, a relationship between aberrant expression levels of GLIS2 and CCND1 and BC development was determined.Conclusion: These observations could help uncover new therapeutic targets for treating patients with BC in the progressive stage.\",\"PeriodicalId\":9224,\"journal\":{\"name\":\"Breast disease\",\"volume\":\"42 1\",\"pages\":\"251-259\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Breast disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3233/BD-220068\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Breast disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/BD-220068","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

背景:乳腺癌(BC)是女性中最常见的癌症，近年来发病率和死亡率不断上升。不同信号通路的中断部分导致乳腺癌。因此，不同的基因通过特定的途径参与了BC肿瘤的发生。方法:本研究对50例患者GLIS2和CCND1基因的表达水平进行了检测。此外，利用芯片分析丰富了涉及上述基因的相关信号通路。结果:BC患者中Cyclin D1表达水平升高，GLIS2表达水平降低。此外，我们还确定了GLIS2和CCND1的异常表达水平与BC发展之间的关系。结论:这些观察结果有助于发现治疗进展期BC患者的新治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

GLIS2 and CCND1 expression levels in breast cancer patients.

Background: Breast cancer (BC) is the most prevalent cancer in women, with increasing incidence and death rates in recent years. Disruptions of different signaling pathways partially cause breast cancer. Hence, different genes through particular pathways are involved in BC tumorigenesis.

Methods: In this study, we evaluated the expression level of GLIS2 and CCND1 genes in 50 patients. Also, in-silico analyses were used to enrich related signaling pathways involving the mentioned genes.

Results: The results showed an increased expression level of Cyclin D1 and decreased expression level of GLIS2 in BC patients. Moreover, a relationship between aberrant expression levels of GLIS2 and CCND1 and BC development was determined.

Conclusion: These observations could help uncover new therapeutic targets for treating patients with BC in the progressive stage.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.