mRNA修饰的蛋白质:写入器,读取器和擦除器。

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Annual review of biochemistry Pub Date : 2023-06-20 DOI:10.1146/annurev-biochem-052521-035330
Mathieu N Flamand, Matthew Tegowski, Kate D Meyer
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引用次数: 14

摘要

在过去的十年中,mRNA修饰已成为细胞中基因表达控制的重要调节因子。在很大程度上,由于广泛检测RNA修饰转录组的工具的发展,研究人员发现了一种多样化的表转录组,它可以作为简单RNA序列之外的基因调控层。在这里,我们回顾了编写、读取和擦除这些标记的蛋白质,特别关注最丰富的内部修饰,n6 -甲基腺苷(m6A)。我们首先描述了沉积和去除m6A和其他修饰的关键酶的发现,并讨论了我们对这些蛋白质的理解如何影响了我们对修饰动力学的看法。然后,我们回顾了m6A读取器蛋白功能的当前模型,以及我们对这些蛋白的认识是如何演变的。最后,我们强调了该领域的重要未来方向,并讨论了尚未解决的关键问题。
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The Proteins of mRNA Modification: Writers, Readers, and Erasers.

Over the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled in large part by the development of tools for detecting RNA modifications transcriptome wide, researchers have uncovered a diverse epitranscriptome that serves as an additional layer of gene regulation beyond simple RNA sequence. Here, we review the proteins that write, read, and erase these marks, with a particular focus on the most abundant internal modification, N6-methyladenosine (m6A). We first describe the discovery of the key enzymes that deposit and remove m6A and other modifications and discuss how our understanding of these proteins has shaped our views of modification dynamics. We then review current models for the function of m6A reader proteins and how our knowledge of these proteins has evolved. Finally, we highlight important future directions for the field and discuss key questions that remain unanswered.

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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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