白细胞介素-6作为子宫内膜异位症相关不孕的有用预测因子:系统综述。

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY International Journal of Fertility & Sterility Pub Date : 2023-08-07 DOI:10.22074/ijfs.2023.557683.1329
Giosue Giordano Incognito, Federica Di Guardo, Ferdinando Antonio Gulino, Fortunato Genovese, Domenico Benvenuto, Chiara Lello, Marco Palumbo
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引用次数: 1

摘要

子宫内膜异位症是一种慢性炎症性疾病,其特征是子宫腔外存在子宫内膜样组织。几位作者报道了炎症标志物水平的变化与子宫内膜异位症和相关不孕的维持或进展之间的关系。白细胞介素-6(IL-6)是子宫内膜异位症中研究最多的细胞因子,在生殖生理中具有重要作用。本研究的目的是系统地回顾子宫内膜异位症相关不孕患者IL-6浓度变化的现有证据。这是一项系统综述,包括截至2022年12月的所有研究,其中测量了血清、腹膜液、卵泡液或子宫内膜活检标本中的IL-6,并将其发现与子宫内膜异位症相关不孕相关。系统综述包括15项研究。血清和腹膜液IL-6浓度升高与子宫内膜异位症相关不孕的发生之间似乎存在相关性。IL-6可能是预测子宫内膜异位症相关不孕的潜在诊断或生物标志物工具。然而,必须考虑影响现有研究的众多偏见,以及子宫内膜异位症研究再现性的挑战。未来的研究应注意可能影响结果的因素,如选择合适的对照组,并仔细考虑影响患者的其他病理条件、子宫内膜异位症分期和病变类型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Interleukin-6 as A Useful Predictor of Endometriosis-Associated Infertility: A Systematic Review.

Endometriosis is a chronic inflammatory disease defined by the presence of endometrial-like tissue outside the uterine cavity. Several authors have reported on the association between changes in inflammatory marker levels and the maintenance or progression of endometriosis and associated infertility. Interleukin-6 (IL-6) is the most studied cytokine in endometriosis and has important functions in reproductive physiology. The aim of this study is to review systematically available evidence about altered IL-6 concentrations in endometriosis-related infertility. This is a systematic review including all studies until December 2022 in which IL-6 in serum, peritoneal fluid, follicular fluid, or endometrial biopsy specimens was measured and that correlated their findings with endometriosis- associated infertility. Fifteen studies were included in the systematic review. There seems to be a correlation between elevated serum and peritoneal fluid IL-6 concentrations and the occurrence of endometriosis-associated infertility. IL-6 may be a potential diagnostic or biomarker tool for the prediction of endometriosis-related infertility. However, the numerous biases affecting the available studies, and challenges in endometriosis research reproducibility must be considered. Future investigations should pay attention to factors that may affect the results, such as the choice of suitable control groups, and carefully consider other pathological conditions affecting the patients, endometriosis stage, and type of lesion.

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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.
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