99mTc-DPD显像中TTR和AL淀粉样变性的脾脏显像。我们是否必须处理与心肌摄取机制不同的机制？

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Hellenic journal of nuclear medicine Pub Date : 2023-05-01 Epub Date: 2023-08-04 DOI:10.1967/s002449912577

Maria Koutelou, Georgios Tziomalos, Vasileios Chatzoglou, Nikitas Pappas, Emmanouil Papanastasiou, Vasiliki Chatzipavlidou, Argyrios Doumas

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引用次数: 0

摘要

99mTc-二膦-1,2-丙二羧酸（99mTc-DPD）目前在欧洲用于诊断心脏淀粉样变性，能够区分轻链（AL）和转甲状腺素（TTR）类型。我们报道了两名患者的脾脏明显可见，第一名患者患有已证实的TTR，第二名患者患有AL型心脏淀粉样变性，心肌摄取仅在第一名患者中达到预期。我们提出了一种假设，即无论疾病类型（AL或TTR）如何，脾脏淀粉样蛋白都存在一种常见的摄取机制，并且可能与心脏摄取机制不同。

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Spleen visualization in both TTR and AL amyloidosis during ^99mTc-DPD scintigraphy. Do we have to deal with a different than the myocardial uptake mechanism?

Technetium-99m- diphosphono-1,2-propanodicarboxylic acid (^99mTc-DPD) is currently used in Europe for the diagnosis of cardiac amyloidosis, being able to distinguish light chain (AL) from transthyretin (TTR) type. We are reporting obvious spleen visualization in two patients suffering the first from proven TTR and the second from AL type of cardiac amyloidosis, with myocardial uptake-as anticipated-only in the first one. We raise the hypothesis that a common uptake mechanism exists for the spleen amyloid regardless of the type of the disease (AL or TTR), and is possibly different than the cardiac uptake mechanism.

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.