端粒和端粒酶:生命史决策中活跃而复杂的角色。

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY Biogerontology Pub Date : 2024-04-01 Epub Date: 2023-08-23 DOI:10.1007/s10522-023-10060-z
Radmila Čapková Frydrychová, Barbora Konopová, Vratislav Peska, Miloslav Brejcha, Michala Sábová
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引用次数: 0

摘要

对人类端粒的研究证实,端粒对生物体的寿命和健康有重大影响。然而,最近的研究表明,最初认为端粒以普遍和核心的方式影响所有真核生物物种的寿命的观点过于简单化了。事实上,来自各种动物物种的研究结果表明,端粒生物学在衰老中的作用比以前认识到的更加微妙和错综复杂。在这里,我们展示了端粒生物学如何因类群而异。我们还展示了端粒生物学如何与基本的生活史特征相对应,并影响物种的生命表以及在生长、体型、繁殖和寿命方面的投资;端粒被假定以一种积极而复杂的方式塑造物种的进化前景。我们的评估是基于动物王国中许多实例的端粒生物学数据,这些实例因生物体的复杂程度和生活史策略而异。
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Telomeres and telomerase: active but complex players in life-history decisions.

Studies on human telomeres have established that telomeres exert a significant influence on lifespan and health of organisms. However, recent research has indicated that the original idea that telomeres affect lifespan in a universal and central manner across all eukaryotic species is an oversimplification. Indeed, findings from a variety of animal species revealed that the role of telomere biology in aging is more subtle and intricate than previously recognized. Here, we show how telomere biology varies depending on the taxon. We also show how telomere biology corresponds to basic life history traits and affects the life table of a species and investments in growth, body size, reproduction, and lifespan; telomeres are hypothesized to shape evolutionary perspectives for species in an active but complex manner. Our evaluation is based on telomere biology data from many examples from throughout the animal kingdom that vary according to the degree of organismal complexity and life history strategies.

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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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