高效合成HIV NNRTI多拉韦林

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2015-03-09 DOI:10.1021/ol503625z

Donald R. Gauthier Jr., *, Benjamin D. Sherry*, Yang Cao, Michel Journet, Guy Humphrey, Tetsuji Itoh, Ian Mangion, David M. Tschaen

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引用次数: 37

摘要

一个有效的和稳健的过程的生产HIV NNRTI多拉韦林的发展是描述。该合成的特点是连续的醛醇反应，作为关键吡啶酮片段从头合成的一部分。采用微批快照法，推导了连续流动醛醇反应的条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Highly Efficient Synthesis of HIV NNRTI Doravirine

The development of an efficient and robust process for the production of HIV NNRTI doravirine is described. The synthesis features a continuous aldol reaction as part of a de novo synthesis of the key pyridone fragment. Conditions for the continuous flow aldol reaction were derived using microbatch snapshots of the flow process.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.