粘菌病综述:发病机制、流行病学、微生物学和诊断。

Q3 Pharmacology, Toxicology and Pharmaceutics Infectious disorders drug targets Pub Date : 2024-01-01 DOI:10.2174/1871526523666230822154407
Aditya Sharma, Md Aftab Alam, Shivang Dhoundiyal, Pramod Kumar Sharma
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引用次数: 0

摘要

粘孢子菌病是由粘孢子菌引起的一种严重的侵袭性真菌感染。这篇综述文章简要概述了粘孢子菌病的发病机制、流行病学、微生物学和诊断。引言部分重点介绍了病原体的主要微生物特性,并深入探讨了粘孢子菌病发病的基本机制,包括真菌在宿主体内的入侵和增殖。疾病描述部分重点介绍了粘孢子菌病的流行病学,包括发病率、风险因素和地理分布。它还探讨了粘孢子菌感染 COVID-19 和糖尿病的具体情况,强调了患有这些疾病的人更容易感染粘孢子菌。病例研究说明了粘孢子菌病的临床表现和相关挑战,强调了早期检测的重要性。此外,综述还讨论了粘孢子菌病的诊断,强调了临床评估、放射成像和微生物检测对准确及时发现感染的重要性。在治疗方面,文章介绍了各种治疗方法,包括抗真菌治疗、外科干预和潜在易感疾病的管理。文章还讨论了与治疗方案相关的局限性和挑战。本综述旨在提供对粘孢子菌病的全面了解,使医疗保健专业人员对其发病机制、流行病学、微生物学和诊断策略有宝贵的见解。通过加强对这种真菌感染的了解和认识,本综述可通过早期诊断和适当治疗改善患者的预后。
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Review on Mucormycosis: Pathogenesis, Epidemiology, Microbiology and Diagnosis.

Mucormycosis is a serious and invasive fungal infection caused by Mucorales fungi. This review article provides a concise overview of the pathogenesis, epidemiology, microbiology, and diagnosis of mucormycosis. The introduction section highlights the key microbiological properties of the pathogen and delves into the underlying mechanisms of mucormycosis pathogenesis, including the invasion and proliferation of the fungus within the host. The description of the disease section focuses on the epidemiology of mucormycosis, including its incidence, risk factors, and geographical distribution. It also explores the specific context of mucormycosis infection about COVID-19 and diabetes mellitus, highlighting the increased susceptibility observed in individuals with these conditions. A case study illustrates the clinical manifestations and challenges associated with mucormycosis, emphasizing the importance of early detection. Additionally, the review discusses the diagnosis of mucormycosis, emphasizing the significance of clinical assessment, radiological imaging, and microbiological tests for accurate and timely detection of the infection. Regarding treatment, the article covers the various therapeutic approaches, including antifungal therapy, surgical interventions, and management of underlying predisposing conditions. The limitations and challenges associated with treatment options are also addressed. This review aims to provide a comprehensive understanding of mucormycosis, equipping healthcare professionals with valuable insights into its pathogenesis, epidemiology, microbiology, and diagnostic strategies. By enhancing knowledge and awareness of this fungal infection, this review can improve patient outcomes through early diagnosis and appropriate management.

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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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