帕金森病伴轻度认知障碍患者与视觉怪球任务相关的脑电图振荡异常交叉频率耦合

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY Clinical EEG and Neuroscience Pub Date : 2023-07-01 DOI:10.1177/15500594221128713
Zübeyir Bayraktaroğlu, Tuba Aktürk, Görsev Yener, Tom A de Graaf, Lütfü Hanoğlu, Ebru Yıldırım, Duygu Hünerli Gündüz, İlayda Kıyı, Alexander T Sack, Claudio Babiloni, Bahar Güntekin
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引用次数: 2

摘要

帕金森病(PD)是一种由多巴胺能神经元变性引起的运动障碍。在病程中,大多数PD患者出现轻度认知障碍(PDMCI)和痴呆,尤其是影响额叶执行功能。在本研究中,我们验证了PDMCI患者在认知信息加工过程中可能存在与额、后皮质区耦合的异常神经生理振荡机制的假设。为了验证这一假设,我们记录了健康对照组在奇数任务中计数视觉目标(罕见)刺激时的事件相关脑电图振荡(EROs)。N = 51),认知未受损PD患者(N = 48)和PDMCI患者(N = 53)。希尔伯特变换用于估计从δ到γ频段的EROs的瞬时相位和幅度,而调制指数计算电极对上的ERO相幅耦合(PAC)。与HC和PD组相比,PDMCI组的特点是(1)δ - θ PAC的后侧地形更多,(2)δ -低频α PAC方向相反,即从后向前而不是从前向后。这些结果表明,在认知需求期间,PDMCI患者的特征是异常的神经生理振荡机制,主要是由支撑额叶到顶叶皮质区功能连接的δ频率引起的。
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Abnormal Cross Frequency Coupling of Brain Electroencephalographic Oscillations Related to Visual Oddball Task in Parkinson's Disease with Mild Cognitive Impairment.

Parkinson's disease (PD) is a movement disorder caused by degeneration in dopaminergic neurons. During the disease course, most of PD patients develop mild cognitive impairment (PDMCI) and dementia, especially affecting frontal executive functions. In this study, we tested the hypothesis that PDMCI patients may be characterized by abnormal neurophysiological oscillatory mechanisms coupling frontal and posterior cortical areas during cognitive information processing. To test this hypothesis, event-related EEG oscillations (EROs) during counting visual target (rare) stimuli in an oddball task were recorded in healthy controls (HC; N = 51), cognitively unimpaired PD patients (N = 48), and PDMCI patients (N = 53). Hilbert transform served to estimate instantaneous phase and amplitude of EROs from delta to gamma frequency bands, while modulation index computed ERO phase-amplitude coupling (PAC) at electrode pairs. As compared to the HC and PD groups, the PDMCI group was characterized by (1) more posterior topography of the delta-theta PAC and (2) reversed delta-low frequency alpha PAC direction, ie, posterior-to-anterior rather than anterior-to-posterior. These results suggest that during cognitive demands, PDMCI patients are characterized by abnormal neurophysiological oscillatory mechanisms mainly led by delta frequencies underpinning functional connectivity from frontal to parietal cortical areas.

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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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