妊娠糖尿病患者乳腺组织、血液和乳汁中的Betatrophin、elabela、asprosin、胰高血糖素和亚脂肪素肽。

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnic & Histochemistry Pub Date : 2023-05-01 DOI:10.1080/10520295.2023.2176546

Adem Yavuz, Mustafa Ata Aydin, Kader Ugur, Suna Aydin, Arzu Senol, Yakup Baykus, Rulin Deniz, İbrahim Sahin, Mehmet Hanifi Yalcin, Berrin Tarakci Gencer, Yaprak Kandemir Deniz, Sefer Ustebay, Zuhal Karaca Karagoz, Elif Emre, Suleyman Aydin

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引用次数: 1

摘要

我们研究了妊娠期糖尿病(GDM)母亲乳汁中asprosin (ASP)、betatrophin、elabela (ELA)、胰高血糖素和亚脂肪素(SUB)的含量，并将其与血中含量进行了比较。我们还研究了这些肽是否由乳房合成。我们调查了12名志愿者GDM母亲和14名非GDM孕妇作为对照。采用酶联免疫吸附法测定多肽，免疫组织化学法测定其组织定位。母乳中含有ASP、betatrophin、ELA、胰高血糖素和SUB，这些肽在初乳、过渡乳和成熟乳中的含量由高到低。牛奶中多肽的含量比血液中多。GDM使乳和血中除ELA外的肽均增加。Betatrophin和ELA在乳腺结缔组织中合成。ASP、胰高血糖素和SUB在乳腺的肺泡组织中合成。母乳中的这些多肽可能有助于新生儿和婴儿胃肠道的发育。

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Betatrophin, elabela, asprosin, glucagon and subfatin peptides in breast tissue, blood and milk in gestational diabetes.

We investigated the presence of asprosin (ASP), betatrophin, elabela (ELA), glucagon and subfatin (SUB) in the milk of mothers with gestational diabetes mellitus (GDM) and compared their levels with blood levels. We also investigated whether these peptides are synthesized by the breast. We investigated 12 volunteer mothers with GDM and 14 pregnant non-GDM control mothers. The peptides were measured using ELISA and their tissue localization was determined using immunohistochemistry. Breast milk contains ASP, betatrophin, ELA, glucagon and SUB. The amount of the peptides ranged from highest to the lowest in colostrum, transitional milk and mature milk. The amount of peptides in the milk was greater than for blood. The peptides, except for ELA, were increased in milk and blood by GDM. Betatrophin and ELA are synthesized in the connective tissue of the breast. ASP, glucagon and SUB are synthesized in the alveolar tissue of the breast. These peptides in breast milk may contribute to the development of the gastrointestinal tract of newborns and infants.

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来源期刊

Biotechnic & Histochemistry 生物-生物工程与应用微生物

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.