sp3/sp2碳比和流体动力学尺寸对静脉注射纳米金刚石在小鼠体内的生物分布动力学的影响。

IF 7.2 1区 医学 Q1 TOXICOLOGY Particle and Fibre Toxicology Pub Date : 2023-08-21 DOI:10.1186/s12989-023-00545-7
Jiyoung Jeong, Soyeon Jeon, Songyeon Kim, Sinuk Lee, Gyuri Kim, Eunsol Bae, Yeonjeong Ha, Seung Whan Lee, Ji-Su Kim, Dong-Jae Kim, Wan-Seob Cho
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引用次数: 0

摘要

背景:纳米金刚石在生物医学应用中的兴趣迅速增长;然而,由于测量困难和合成/纯化技术有限,对它们的生物动力学知之甚少。在本研究中,我们通过静脉注射研究了爆震合成的NDs在小鼠中的分布动力学,以评估决定颗粒行为的参数。我们制备了两种独特的ND,通过用血清蛋白包被它们来控制sp3/sp2碳比和颗粒大小。将四个对照样品静脉注射到小鼠体内,并在注射后30分钟和1、7和28天评估组织分布和清除率。结果:sp3/sp2碳比与NDs的器官分布无关。然而,流体动力学大小与器官分布水平呈正相关:肝脏呈负相关,脾脏和肺部呈正相关。此外,肺中NDs的沉积水平表明,小于300nm的颗粒可以避免肺沉积。最后,在注射了控制流体动力学大小的炭黑纳米颗粒的小鼠中观察到了类似的器官分布模式。结论:总之,NDs的组织分布不是由sp3/sp2碳比调节的,而是由流体动力学尺寸调节的,这可以为靶向NDs的细胞组织提供有用的信息。此外,NDs的器官分布模式可能不是NDs特有的,但也可以应用于其他纳米颗粒,如炭黑。
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Effect of sp3/sp2 carbon ratio and hydrodynamic size on the biodistribution kinetics of nanodiamonds in mice via intravenous injection.

Background: Nanodiamonds (NDs) have gained a rapidly growing interest in biomedical applications; however, little is known regarding their biokinetics owing to difficulties in measurements and limited synthesis/purification technologies. In this study, we investigated the distribution kinetics of detonation-synthesized NDs in mice via intravenous injection to evaluate the parameters that determine the behavior of the particles. We prepared two distinctive NDs that controlled the sp3/sp2 carbon ratio and particle size by coating them with serum proteins. The four control samples were intravenously injected into mice, and tissue distribution and clearance were evaluated at 30 min and 1, 7, and 28 days post-injection.

Results: The sp3/sp2 carbon ratio showed no correlation with the organ distribution of the NDs. However, hydrodynamic size showed an excellent correlation with organ distribution levels: a negative correlation in the liver and positive correlations in the spleen and lungs. Furthermore, the deposition levels of NDs in the lung suggest that particles smaller than 300 nm could avoid lung deposition. Finally, a similar organ distribution pattern was observed in mice injected with carbon black nanoparticles controlled hydrodynamic size.

Conclusions: In conclusion, the tissue distribution of NDs is modulated not by the sp3/sp2 carbon ratio but by the hydrodynamic size, which can provide helpful information for targeting the tissue of NDs. Furthermore, the organ distribution pattern of the NDs may not be specific to NDs but also can apply to other nanoparticles, such as carbon black.

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来源期刊
CiteScore
15.90
自引率
4.00%
发文量
69
审稿时长
6 months
期刊介绍: Particle and Fibre Toxicology is an online journal that is open access and peer-reviewed. It covers a range of disciplines such as material science, biomaterials, and nanomedicine, focusing on the toxicological effects of particles and fibres. The journal serves as a platform for scientific debate and communication among toxicologists and scientists from different fields who work with particle and fibre materials. The main objective of the journal is to deepen our understanding of the physico-chemical properties of particles, their potential for human exposure, and the resulting biological effects. It also addresses regulatory issues related to particle exposure in workplaces and the general environment. Moreover, the journal recognizes that there are various situations where particles can pose a toxicological threat, such as the use of old materials in new applications or the introduction of new materials altogether. By encompassing all these disciplines, Particle and Fibre Toxicology provides a comprehensive source for research in this field.
期刊最新文献
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