乙醇消融治疗年轻人甲状腺囊肿的疗效和生活质量。

IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM European Thyroid Journal Pub Date : 2023-08-11 DOI:10.1530/ETJ-23-0085
Milan Halenka, Hana Munteanu, Radko Obereigneru, Roman Dohnal, David Karasek, Jan Schovanek
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引用次数: 0

摘要

目的:超声引导下经皮乙醇注射治疗(US-PEIT)用于复发性症状性甲状腺囊肿患者,作为一种可靠的替代手术治疗方法。年轻患者通常不希望接受手术,如果可以的话,他们更喜欢乙醇消融。这种方法对生活质量的影响是决定治疗方案的重要因素,特别是在预期寿命长且无合并症的年轻人中。方法:我们在2015年至2020年期间对15-30岁的年轻患者进行了US-PEIT。评估患者的总体生活质量(QoL)、自我报告的压迫症状和颈部外观。结果:本组59例患者共63个囊肿,女性多于男性,平均年龄23.8岁。在12个月内,大约需要1.5 mL的酒精注射才能达到90.7%的平均囊肿体积缩小率。该方法在任何患者中都没有失败;其中46%的人进行了一次US-PEIT会话。该方法显著改善了每例患者的症状,总评分差异显著(P < 0.001)。症状总评分与初始囊肿体积相关(P = 0.002;R = 0.395)。在最后一次US-PEIT后6个月,SF-36的平均生活质量评分与年龄对应的标准相比,身体成分总结为56.5 (P < 0.001),而精神成分总结为47.7 (P = 0.125),差异无统计学意义。结论:US-PEIT对于年轻人是一种安全有效的方法,可以改善美容和主观抱怨,也应考虑作为年轻人的一线治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Ethanol ablation of thyroid cysts in the young with a focus on efficacy and quality of life.

Objective: Ultrasound-guided percutaneous ethanol injection therapy (US-PEIT) is used in patients with recurrent symptomatic thyroid cysts as a credible alternative to surgery. Young patients commonly do not wish to undergo surgery and prefer ethanol ablation, if available. The effect of this approach on quality of life is an essential factor in deciding on the treatment options, especially in the young with a long life expectancy and no comorbidity.

Methods: We performed US-PEIT in a cohort of young patients, 15-30 years, from 2015 to 2020. The patients' general quality of life (QoL), self-reported compression symptoms and neck appearance were evaluated.

Results: The cohort comprised 59 patients with 63 cysts, more women than men, with a mean age of 23.8 years. About 1.5 mL of injected alcohol were needed to reach a 90.7% mean cyst volume reduction ratio in 12 months. The method did not fail in any of the patients; a single US-PEIT session was undertaken in 46% of them. The procedure significantly improved each of the patients' symptoms with a significant total score difference (P < 0.001). The total symptom score correlated with the initial cyst volume (P = 0.002; r = 0.395). The mean QoL score by SF-36 6 months after the last US-PEIT was significantly different for physical component summary 56.5 (P < 0.001) but not different for mental component summary 47.7 (P = 0.125), compared to age-corresponding norms.

Conclusions: US-PEIT is a safe and effective method for the young, leading to improvements in cosmetic and subjective complaints, and should also be considered as first-line treatment in the young.

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来源期刊
European Thyroid Journal
European Thyroid Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.70
自引率
2.10%
发文量
156
期刊介绍: The ''European Thyroid Journal'' publishes papers reporting original research in basic, translational and clinical thyroidology. Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.
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