Nguyen Thuy Linh, Ngo Thu Hang, Bui Khac Cuong, Dang Thuy Linh, Nham Thi Phuong Linh, Do Nguyen-Van, Tran Ngoc Dzung, Can Van Mao, Dang Thanh Chung, Le Tri Chinh, Nguyen Phu Hung, Hoang Van Tong, Nguyen Linh Toan
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Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma.
Aim: Ovarian cancer is a serious malignancy with high prevalence and mortality.
Methods: We isolated and characterized an ovarian high-grade serous cancer cell line (M4) from a tumor of a Vietnamese patient with ovarian carcinoma.
Results: The M4 cancer cell line showed good proliferation and stability in culture. Morphologically, the M4 cells showed similar characteristics to tumor cells such as a polyhedral shape, large irregular nuclei, high nuclear/cytoplasmic ratio, high nuclear density and expressing cancer markers like CA125, p53 and Ki67 markers.
Conclusion: We have successfully isolated and characterized the M4 cell line from a Vietnamese patient with ovarian carcinoma.
期刊介绍：
Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries
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