Tan Thanh Nguyen, Mai Thi Xuan Truong, Dung Ngoc Lam, Tuyen Thi Thanh Le, Mai Tuyet Vi, Thanh My Tran, Thu Pham Minh Vo, Suol Thanh Pham, Bao Lam Thai Tran, Thang Nguyen, Lam Van Nguyen
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引用次数: 0
摘要
背景:哮喘患者的药物依从性提高了治疗的有效性,但在低收入和中等收入国家的一些研究仍然显示出一些局限性。我们的研究旨在确定药剂师主导的干预措施是否可以增加哮喘门诊患者的药物依从性,提高治疗效果,缓解症状严重程度。方法:对247例年龄≥16岁的哮喘门诊患者进行随机对照试验,住院时按1:1比例随机,出院后1个月重复。主要结果是检测组间药物依从性的差异。采用一般药物依从性量表(GMAS)评估依从性。对问卷收集的数据进行编码,录入SPSS_20进行统计分析;结果:纳入247例患者(干预组123例,对照组124例),其中男性61.1%。干预后,干预组依从率高于对照组(94.3% vs. 82.8%, p = 0.001)。干预组患者的行为和知识均有所提高(p < 0.05)。干预组哮喘症状明显缓解(p = 0.014)。药师主导干预对依从率的影响较高,OR: 3.550, 95% CI: 1.378 ~ 9.143, p = 0.009。结论:药物干预可提高患者的服药依从性和治疗效果,其结果不应想当然;在这方面应进行进一步的研究。
Effect of Pharmacist-Led Interventions on Medication Adherence among Vietnamese Patients with Asthma: A Randomized Controlled Trial.
Background: Medication adherence in asthmatic patients enhances the effectiveness of treatments, but some studies in low and middle-income countries still show some limitations. Our study aimed to determine if pharmacist-led interventions could increase medication adherence, improve treatment effectiveness, and relieve symptom severity in outpatients with asthma.
Methods: We conducted a randomized, controlled trial on 247 asthmatic outpatients (aged ≥ 16) with a 1:1 ratio randomization at the hospitalization time and repeated after 1-month discharge. The primary outcome was to detect the difference in medication adherence between groups. Adherence was assessed by the general medication adherence scale (GMAS). Data collected by questionnaire was coded and entered into SPSS_20 for statistical analysis; Results: 247 patients (123 intervention, 124 control) were enrolled (61.1% male). After intervention, the adherence rate was higher among the intervention group than the control group (94.3% vs. 82.8%, p = 0.001). Patient behavior and knowledge were enhanced in the intervention group (p < 0.05). Asthma symptoms were relieved in the intervention group (p = 0.014). Pharmacist-led interventions on adherence rate were higher with OR: 3.550, 95% CI: 1.378-9.143, p = 0.009.
Conclusions: pharmaceutical intervention could improve medication adherence, treatment efficacy, and the outcome should not be taken for granted; further research should be carried out in this regard.
期刊介绍:
"Advances in Respiratory Medicine" is a new international title for "Pneumonologia i Alergologia Polska", edited bimonthly and addressed to respiratory professionals. The Journal contains peer-reviewed original research papers, short communications, case-reports, recommendations of the Polish Respiratory Society concerning the diagnosis and treatment of lung diseases, editorials, postgraduate education articles, letters and book reviews in the field of pneumonology, allergology, oncology, immunology and infectious diseases. "Advances in Respiratory Medicine" is an open access, official journal of Polish Society of Lung Diseases, Polish Society of Allergology and National Research Institute of Tuberculosis and Lung Diseases.