当前和新出现的外周动脉疾病的医学治疗:文献综述。

IF 3.1 Q2 PHARMACOLOGY & PHARMACY Advanced pharmaceutical bulletin Pub Date : 2023-03-01 DOI:10.34172/apb.2023.025
AmirAhmad Arabzadeh, Elnaz Faghfuri, Saiedeh Razi Soofiyani, Elaheh Dalir Abdolahinia, Samaneh Siapush, Kazem Nejati-Koshki, Bita Shahrami, Vahid Asghariazar, Yasamin Pahlavan
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引用次数: 1

摘要

尽管在过去的几十年里血管内技术得到了改进,但外周动脉疾病(PAD)的患病率仍然在增加,实际治疗方法有限,任何干预对严重肢体缺血(CLI)的时间影响都很差。大多数常见的治疗方法都不适合许多患者,因为他们有潜在的疾病,包括衰老和糖尿病。一方面,由于某些个体的禁忌症,目前的治疗方法存在局限性,另一方面,常见药物如抗凝血剂会产生许多副作用。因此,除了传统的药物联合治疗外,再生医学、细胞疗法、纳米疗法、基因疗法、靶向治疗等新的治疗策略被认为是治疗PAD的新方法。编码特定蛋白质的遗传物质具有开发治疗方法的潜在未来。治疗性血管生成的新方法直接使用源自关键生物分子的血管生成因子,如基因、蛋白质或基于细胞的治疗来诱导成人组织中的血管形成,以启动缺血肢体的恢复过程。由于PAD患者致残的死亡率和发病率较高,考虑到这些患者的治疗选择有限,开发新的治疗策略以防止PAD进展和延长预期寿命,并预防威胁并发症是迫切需要的。本文旨在介绍当前和新的PAD治疗策略,为减轻患者的痛苦带来新的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Current and Novel Emerging Medical Therapies for Peripheral Artery Disease: A Literature Review.

Despite the improvements in endovascular techniques during the last decades, there is still an increase in the prevalence of peripheral artery disease (PAD) with limited practical treatment, which timeline impact of any intervention for critical limb ischemia (CLI) is poor. Most common treatments are not suitable for many patients due to their underlying diseases, including aging and diabetes. On the one hand, there are limitations for current therapies due to the contraindications of some individuals, and on the other hand, there are many side effects caused by common medications, for instance, anticoagulants. Therefore, novel treatment strategies like regenerative medicine, cell-based therapies, Nano-therapy, gene therapy, and targeted therapy, besides other traditional drugs combination therapy for PAD, are newly considered promising therapy. Genetic material encoding for specific proteins concludes with a potential future for developed treatments. Novel approaches for therapeutic angiogenesis directly used the angiogenetic factors originating from key biomolecules such as genes, proteins, or cell-based therapy to induce blood vessel formation in adult tissues to initiate the recovery process in the ischemic limb. As PAD is associated with high mortality and morbidity of patients causing disability, considering the limited treatment choices for these patients, developing new treatment strategies to prevent PAD progression and extending life expectancy, and preventing threatening complications is urgently needed. This review aims to introduce the current and the novel strategies for PAD treatment that lead to new challenges for relief the patient's suffered from the disorder.

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来源期刊
Advanced pharmaceutical bulletin
Advanced pharmaceutical bulletin PHARMACOLOGY & PHARMACY-
CiteScore
6.80
自引率
2.80%
发文量
51
审稿时长
12 weeks
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