{"title":"伊朗癌症研究所食管鳞状细胞癌术前标本中HER2表达频率、MMR缺失和PI3KCA突变","authors":"Samaneh Salarvand Farzaneh Bagheri, Mahsa Gholizadeh, Sima Sharifi, Pooneh Panahi, Ebrahim Esmati, Marzieh Lashkari, Amirmohsen Jalaeefar, Mohammad Shirkhoda, Reza Shahsiah, Reza Ghalehtaki","doi":"10.30699/IJP.2023.563358.2989","DOIUrl":null,"url":null,"abstract":"<p><strong>Background & objective: </strong>Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of <i>HER2</i> expression, <i>MMR</i> deficiency, and <i>PI3KCA</i> mutation are not well defined.</p><p><strong>Methods: </strong>We carried out <i>HER2/neu</i> expression, <i>dMMR/MSI</i> high, and <i>PI3KCA</i> mutation analysis in specimens of patients with ESCC. We accessed archival tissue blocks related to specimens of 68 ESCC cases at the time of surgery following neoadjuvant chemoradiation. These patients underwent surgery during 2013-2018 at the Cancer Institute of Iran affiliated with the Tehran University of Medical Sciences in Tehran.</p><p><strong>Results: </strong>None of the patients showed <i>HER2</i> expression, <i>dMMR/MSI</i> high, or <i>PI3K</i> mutations.</p><p><strong>Conclusion: </strong><i>dMMR/MSI-H</i> and <i>PI3KCA</i> mutation and <i>HER2</i> expression may not be reliable andfrequent targets for systemic therapy in patients with esophageal SCC.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"18 1","pages":"96-103"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293601/pdf/","citationCount":"0","resultStr":"{\"title\":\"Frequency of HER2 Expression, MMR Deficiency, and PI3KCA Mutation in Pretreated Surgical Specimens of Patients with Esophageal Squamous Cell Carcinoma in Iran Cancer Institute.\",\"authors\":\"Samaneh Salarvand Farzaneh Bagheri, Mahsa Gholizadeh, Sima Sharifi, Pooneh Panahi, Ebrahim Esmati, Marzieh Lashkari, Amirmohsen Jalaeefar, Mohammad Shirkhoda, Reza Shahsiah, Reza Ghalehtaki\",\"doi\":\"10.30699/IJP.2023.563358.2989\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background & objective: </strong>Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of <i>HER2</i> expression, <i>MMR</i> deficiency, and <i>PI3KCA</i> mutation are not well defined.</p><p><strong>Methods: </strong>We carried out <i>HER2/neu</i> expression, <i>dMMR/MSI</i> high, and <i>PI3KCA</i> mutation analysis in specimens of patients with ESCC. We accessed archival tissue blocks related to specimens of 68 ESCC cases at the time of surgery following neoadjuvant chemoradiation. These patients underwent surgery during 2013-2018 at the Cancer Institute of Iran affiliated with the Tehran University of Medical Sciences in Tehran.</p><p><strong>Results: </strong>None of the patients showed <i>HER2</i> expression, <i>dMMR/MSI</i> high, or <i>PI3K</i> mutations.</p><p><strong>Conclusion: </strong><i>dMMR/MSI-H</i> and <i>PI3KCA</i> mutation and <i>HER2</i> expression may not be reliable andfrequent targets for systemic therapy in patients with esophageal SCC.</p>\",\"PeriodicalId\":38900,\"journal\":{\"name\":\"Iranian Journal of Pathology\",\"volume\":\"18 1\",\"pages\":\"96-103\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293601/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30699/IJP.2023.563358.2989\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30699/IJP.2023.563358.2989","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Frequency of HER2 Expression, MMR Deficiency, and PI3KCA Mutation in Pretreated Surgical Specimens of Patients with Esophageal Squamous Cell Carcinoma in Iran Cancer Institute.
Background & objective: Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of HER2 expression, MMR deficiency, and PI3KCA mutation are not well defined.
Methods: We carried out HER2/neu expression, dMMR/MSI high, and PI3KCA mutation analysis in specimens of patients with ESCC. We accessed archival tissue blocks related to specimens of 68 ESCC cases at the time of surgery following neoadjuvant chemoradiation. These patients underwent surgery during 2013-2018 at the Cancer Institute of Iran affiliated with the Tehran University of Medical Sciences in Tehran.
Results: None of the patients showed HER2 expression, dMMR/MSI high, or PI3K mutations.
Conclusion: dMMR/MSI-H and PI3KCA mutation and HER2 expression may not be reliable andfrequent targets for systemic therapy in patients with esophageal SCC.
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