原发性皮肤毛霉病:一种预后不良的坏死性软组织感染。

Q3 Pharmacology, Toxicology and Pharmaceutics Infectious disorders drug targets Pub Date : 2023-01-01 DOI:10.2174/1871526523666230504114801
Poornima Dogra, Nidhi Singla, Robin Kaushik, Simrandeep Singh, Varsha Gupta
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引用次数: 0

摘要

背景:皮肤毛霉病是一种持续发生的罕见真菌感染。由于其高致死率,需要积极的手术清创和及时的抗真菌药物治疗。为了防止同样的情况发生,外科医生需要高度的临床怀疑。病例介绍:我们提出两例皮肤毛霉病,其中患者死亡,突出病情的严重性。一名患者患有下肢溃疡并患有糖尿病,另一名患者在肌肉注射后出现臀脓肿。组织样品中分别生长有根霉(Rhizopus arrhizus)和棘霉(Apophysomyces sp.)。两例患者均给予两性霉素B治疗,并行广泛清创。讨论:皮肤毛霉病可以在免疫功能正常的人群中报告,并且需要早期识别该实体作为任何不愈合的坏死性溃疡的鉴别诊断。结论:周边初级和二级保健中心应对技术和临床工作人员进行适当的培训和教育,以避免遗漏毛霉病病例,并为外科患者皮肤毛霉病的预后提供更好的预后。
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Primary Cutaneous Mucormycosis: A Necrotising Soft Tissue Infection with Poor Prognosis.

Background: Cutaneous mucormycosis is an unusual fungal infection that continues to occur. It needs aggressive surgical debridement and timely administration of antifungals due to its high fatality rate. High clinical suspicion on the part of a surgeon is required to prevent the same.

Case presentation: We present two cases of cutaneous mucormycosis in which the patients succumbed to death, highlighting the seriousness of the condition. One patient had a lower leg ulcer and was diabetic, and the other patient had a gluteal abscess following an intramuscular injection. Tissue samples grew Rhizopus arrhizus and Apophysomyces sp., respectively. Both patients were treated with amphotericin B, and extensive debridement was performed.

Discussion: Cutaneous mucormycosis can be reported in immunocompetent people, and there is a need for early recognition of the entity as a differential diagnosis of any nonhealing necrotic ulcer.

Conclusion: Proper training and education of technical and clinical staff should be done at peripheral primary and secondary care centres so as not to miss out on cases of mucormycosis and for better prognosis in a cutaneous variety of mucormycosis in surgical patients.

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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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