骨盆骨肉瘤,预后因素和治疗:文献综述。

IF 2.5 3区 医学 Q1 SURGERY Scandinavian Journal of Surgery Pub Date : 2023-09-01 DOI:10.1177/14574969231181504
Minna K Laitinen, Michael C Parry, Guy V Morris, Lee M Jeys
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引用次数: 0

摘要

原发性骨肉瘤是一种罕见的恶性间质肿瘤。最常见的骨肉瘤是骨原性肉瘤、尤文氏肉瘤和软骨肉瘤。多年来,预后有所改善,但骨肉瘤仍然是危及生命的肿瘤,需要多学科的诊断和治疗方法。骨盆骨肉瘤对骨科肿瘤学家来说是一个独特的挑战,因为它缺乏天然的解剖屏障,靠近重要的神经血管结构,并且在切除肿瘤后对任何骨盆重建都有很高的机械要求。虽然放疗在尤文氏肉瘤中起着重要的作用,而化疗在尤文氏肉瘤和骨原性肉瘤中都起着重要的作用,但手术仍然是这三种肿瘤的主要治疗选择。虽然外半骨盆切除术仍然是一种选择,但手术的主要目的是保留肢体。肿瘤完全切除后,需要重建骨缺损。修复缺损的方法包括假体或生物修复。重建的方法取决于肿瘤的位置和切除所需的手术。本文的目的是根据作者的经验,深入了解骨盆骨肉瘤,其肿瘤和手术结果,以及治疗方案。
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Pelvic bone sarcomas, prognostic factors, and treatment: A narrative review of the literature.

Primary sarcomas of bone are rare malignant mesenchymal tumors. The most common bone sarcomas are osteosarcoma, Ewing's sarcoma, and chondrosarcoma. The prognosis has improved over the years, but bone sarcomas are still life-threatening tumors that need a multidisciplinary approach for diagnosis and treatment. Bone sarcomas arising in the pelvis present a unique challenge to orthopedic oncologists due to the absence of natural anatomical barriers, the close proximity of vital neurovascular structures, and the high mechanical demands placed on any pelvic reconstruction following the excision of the tumor. While radiotherapy has an important role especially in Ewing's sarcoma and chemotherapy for both Ewing's sarcoma and osteosarcoma, surgery remains the main choice of treatment for all three entities. While external hemipelvectomy has remained one option, the main aim of surgery is limb salvage. After complete tumor resection, the bone defect needs to be reconstructed. Possibilities to reconstruct the defect include prosthetic or biological reconstruction. The method of reconstruction is dependent on the location of tumor and the surgery required for its removal. The aim of this article is to give an insight into pelvic bone sarcomas, their oncological and surgical outcomes, and the options for treatment based on the authors' experiences.

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来源期刊
CiteScore
5.50
自引率
4.20%
发文量
37
审稿时长
6-12 weeks
期刊介绍: The Scandinavian Journal of Surgery (SJS) is the official peer reviewed journal of the Finnish Surgical Society and the Scandinavian Surgical Society. It publishes original and review articles from all surgical fields and specialties to reflect the interests of our diverse and international readership that consists of surgeons from all specialties and continents.
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