长链非编码RNA与剪接小RNA之间的串扰作为一种新的癌症生物标志物。

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Non-Coding RNA Pub Date : 2023-07-31 DOI:10.3390/ncrna9040042
Maram Arafat, Ruth Sperling
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引用次数: 2

摘要

非编码rna (ncRNAs)在调节细胞过程中发挥着多种作用,并与病理状况有关,包括癌症,其中ncRNAs之间的相互作用发挥作用。与此相关的是(i) microRNAs (miRNAs),主要被称为细胞质中基因表达的负调控因子。然而,在细胞核中鉴定mirna提示了新的核功能,并且(ii)长链非编码RNA (lncRNA)在多个水平上调控基因表达。最近在人乳腺癌和宫颈癌细胞的上质体中发现了miRNA,揭示了lncRNA的新靶点。在这里,我们强调了lncRNA和来自同一基因组区域表达的上质体miRNA之间具有互补序列的串扰的潜在情况。通过RNA:RNA碱基配对,如发生在癌症中,其中一方(miRNA或lncRNA)水平的变化会影响另一方的水平,这可能与乳腺癌和宫颈癌有关。一个例子是剪接体mir-7704作为致癌lncRNA HAGLR的负调节因子。由于剪接体miRNA的表达是细胞类型特异性的,因此这里列出的顺式相互作用lncRNA:剪接体miRNA可能只是冰山一角,这种相互作用可能与其他癌症有关。因此,我们强调lncRNA:剪接体miRNA相互作用作为癌症诊断和治疗的新靶点的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Crosstalk between Long Non-Coding RNA and Spliceosomal microRNA as a Novel Biomarker for Cancer.

Non-coding RNAs (ncRNAs) play diverse roles in regulating cellular processes and have been implicated in pathological conditions, including cancer, where interactions between ncRNAs play a role. Relevant here are (i) microRNAs (miRNAs), mainly known as negative regulators of gene expression in the cytoplasm. However, identification of miRNAs in the nucleus suggested novel nuclear functions, and (ii) long non-coding RNA (lncRNA) regulates gene expression at multiple levels. The recent findings of miRNA in supraspliceosomes of human breast and cervical cancer cells revealed new candidates of lncRNA targets. Here, we highlight potential cases of crosstalk between lncRNA and supraspliceosomal miRNA expressed from the same genomic region, having complementary sequences. Through RNA:RNA base pairing, changes in the level of one partner (either miRNA or lncRNA), as occur in cancer, could affect the level of the other, which might be involved in breast and cervical cancer. An example is spliceosomal mir-7704 as a negative regulator of the oncogenic lncRNA HAGLR. Because the expression of spliceosomal miRNA is cell-type-specific, the list of cis-interacting lncRNA:spliceosomal miRNA presented here is likely just the tip of the iceberg, and such interactions are likely relevant to additional cancers. We thus highlight the potential of lncRNA:spliceosomal miRNA interactions as novel targets for cancer diagnosis and therapies.

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来源期刊
Non-Coding RNA
Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
6.70
自引率
4.70%
发文量
74
审稿时长
10 weeks
期刊介绍: Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.
期刊最新文献
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