病变人体皮肤模型的体外三维生物制造。

IF 11.3 1区 医学 Q1 Medicine Biomaterials Research Pub Date : 2023-08-22 DOI:10.1186/s40824-023-00415-5
Minjun Ahn, Won-Woo Cho, Wonbin Park, Jae-Seong Lee, Min-Ju Choi, Qiqi Gao, Ge Gao, Dong-Woo Cho, Byoung Soo Kim
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引用次数: 1

摘要

人体皮肤是位于身体最外层的器官;因此,它经常表现出明显的生理健康迹象。传统动物研究中的伦理问题和遗传差异增加了对模拟天然皮肤结构和功能特征的替代体外平台的需求。尽管体外皮肤模型在过去几十年中取得了重大进展,但与用于健康皮肤模型的策略相比,需要不同的可再生生物制造策略来重现患病人体皮肤的病理特征。为了解释具有病理特征的人体皮肤建模,我们首先总结了健康人体皮肤的结构和功能特征。然后,我们提供了如何在体外重建患病人类皮肤模型的广泛概述,包括受伤,糖尿病,皮肤癌,特应性和其他病理皮肤类型的模型。最后,对疾病皮肤建模的研究进展进行了展望,并对皮肤工程的进一步发展提出了技术展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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3D biofabrication of diseased human skin models in vitro.

Human skin is an organ located in the outermost part of the body; thus, it frequently exhibits visible signs of physiological health. Ethical concerns and genetic differences in conventional animal studies have increased the need for alternative in vitro platforms that mimic the structural and functional hallmarks of natural skin. Despite significant advances in in vitro skin modeling over the past few decades, different reproducible biofabrication strategies are required to reproduce the pathological features of diseased human skin compared to those used for healthy-skin models. To explain human skin modeling with pathological hallmarks, we first summarize the structural and functional characteristics of healthy human skin. We then provide an extensive overview of how to recreate diseased human skin models in vitro, including models for wounded, diabetic, skin-cancer, atopic, and other pathological skin types. We conclude with an outlook on diseased-skin modeling and its technical perspective for the further development of skin engineering.

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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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