超声聚焦过程中细胞路径的快速高效计算。

IF 2.5 4区 医学 Q1 ACOUSTICS Ultrasonic Imaging Pub Date : 2023-09-01 Epub Date: 2023-08-29 DOI:10.1177/01617346231195598
Charles F Babbs, Mary V Lang
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引用次数: 0

摘要

这项生物物理分析探索了悬浮在水性流体中并经历渐进或驻波的白细胞大小颗粒运动的第一原理物理学。在许多当前的应用中,细胞逐渐被推向驻波的节点,提供一定程度的声聚焦和细胞在垂直于声音传播方向的层中的集中。在这里,专门针对水的粘性状态和小直径微观球体(如活细胞)分析了这种现象的潜在生物力学。由此产生的数学模型导致蠕变或漂移速度作为声音频率、振幅、波长、流体粘度、边界尺寸和边界反射率的函数的单一代数表达式。该表达式可以通过简单快速的计算机算法进行数值集成,以演示粒子的净运动作为时间的函数,为超声细胞聚焦的各种新兴应用中的优化提供指导。
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Rapid and Efficient Computation of Cell Paths During Ultrasonic Focusing.

This biophysical analysis explores the first-principles physics of movement of white blood cell sized particles, suspended in an aqueous fluid and experiencing progressive or standing waves of acoustic pressure. In many current applications the cells are gradually nudged or herded toward the nodes of the standing wave, providing a degree of acoustic focusing and concentration of the cells in layers perpendicular to the direction of sound propagation. Here the underlying biomechanics of this phenomenon are analyzed specifically for the viscous regime of water and for small diameter microscopic spheroids such as living cells. The resulting mathematical model leads to a single algebraic expression for the creep or drift velocity as a function of sound frequency, amplitude, wavelength, fluid viscosity, boundary dimensions, and boundary reflectivity. This expression can be integrated numerically by a simple and fast computer algorithm to demonstrate net movement of particles as a function of time, providing a guide to optimization in a variety of emerging applications of ultrasonic cell focusing.

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来源期刊
Ultrasonic Imaging
Ultrasonic Imaging 医学-工程:生物医学
CiteScore
5.10
自引率
8.70%
发文量
15
审稿时长
>12 weeks
期刊介绍: Ultrasonic Imaging provides rapid publication for original and exceptional papers concerned with the development and application of ultrasonic-imaging technology. Ultrasonic Imaging publishes articles in the following areas: theoretical and experimental aspects of advanced methods and instrumentation for imaging
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