血液动力学、氧合和淋巴细胞参数预测COVID-19死亡率。

IF 2.7 Q2 PATHOLOGY Pathophysiology Pub Date : 2023-08-02 DOI:10.3390/pathophysiology30030025
Choirina Windradi, Tri Pudy Asmarawati, Alfian Nur Rosyid, Erika Marfiani, Bagus Aulia Mahdi, Okla Sekar Martani, Giarena Giarena, Esthiningrum Dewi Agustin, Milanitalia Gadys Rosandy
{"title":"血液动力学、氧合和淋巴细胞参数预测COVID-19死亡率。","authors":"Choirina Windradi,&nbsp;Tri Pudy Asmarawati,&nbsp;Alfian Nur Rosyid,&nbsp;Erika Marfiani,&nbsp;Bagus Aulia Mahdi,&nbsp;Okla Sekar Martani,&nbsp;Giarena Giarena,&nbsp;Esthiningrum Dewi Agustin,&nbsp;Milanitalia Gadys Rosandy","doi":"10.3390/pathophysiology30030025","DOIUrl":null,"url":null,"abstract":"<p><p>The mortality of COVID-19 patients has left the world devastated. Many scoring systems have been developed to predict the mortality of COVID-19 patients, but several scoring components cannot be carried out in limited health facilities. Herein, the authors attempted to create a new and easy scoring system involving mean arterial pressure (MAP), PF Ratio, or SF ratio-respiration rate (SF Ratio-R), and lymphocyte absolute, which were abbreviated as MPL or MSLR functioning, as a predictive scoring system for mortality within 30 days for COVID-19 patients. Of 132 patients with COVID-19 hospitalized between March and November 2021, we followed up on 96 patients. We present bivariate and multivariate analyses as well as the area under the curve (AUC) and Kaplan-Meier charts. From 96 patients, we obtained an MPL score of 3 points: MAP < 75 mmHg, PF Ratio < 200, and lymphocyte absolute < 1500/µL, whereas the MSLR score was 6 points: MAP < 75 mmHg, SF Ratio < 200, lymphocyte absolute < 1500/µL, and respiration rate 24/min. The MPL cut-off point is 2, while the MSLR is 4. MPL and MSLR have the same sensitivity (79.1%) and specificity (75.5%). The AUC value of MPL vs. MSLR was 0.802 vs. 0.807. The MPL ≥ 2 and MSLR ≥ 4 revealed similar predictions for survival within 30 days (<i>p</i> < 0.05). Conclusion: MPL and MSLR scores are potential predictors of mortality in COVID-19 patients within 30 days in a resource-limited country.</p>","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443272/pdf/","citationCount":"0","resultStr":"{\"title\":\"Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality.\",\"authors\":\"Choirina Windradi,&nbsp;Tri Pudy Asmarawati,&nbsp;Alfian Nur Rosyid,&nbsp;Erika Marfiani,&nbsp;Bagus Aulia Mahdi,&nbsp;Okla Sekar Martani,&nbsp;Giarena Giarena,&nbsp;Esthiningrum Dewi Agustin,&nbsp;Milanitalia Gadys Rosandy\",\"doi\":\"10.3390/pathophysiology30030025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The mortality of COVID-19 patients has left the world devastated. Many scoring systems have been developed to predict the mortality of COVID-19 patients, but several scoring components cannot be carried out in limited health facilities. Herein, the authors attempted to create a new and easy scoring system involving mean arterial pressure (MAP), PF Ratio, or SF ratio-respiration rate (SF Ratio-R), and lymphocyte absolute, which were abbreviated as MPL or MSLR functioning, as a predictive scoring system for mortality within 30 days for COVID-19 patients. Of 132 patients with COVID-19 hospitalized between March and November 2021, we followed up on 96 patients. We present bivariate and multivariate analyses as well as the area under the curve (AUC) and Kaplan-Meier charts. From 96 patients, we obtained an MPL score of 3 points: MAP < 75 mmHg, PF Ratio < 200, and lymphocyte absolute < 1500/µL, whereas the MSLR score was 6 points: MAP < 75 mmHg, SF Ratio < 200, lymphocyte absolute < 1500/µL, and respiration rate 24/min. The MPL cut-off point is 2, while the MSLR is 4. MPL and MSLR have the same sensitivity (79.1%) and specificity (75.5%). The AUC value of MPL vs. MSLR was 0.802 vs. 0.807. The MPL ≥ 2 and MSLR ≥ 4 revealed similar predictions for survival within 30 days (<i>p</i> < 0.05). Conclusion: MPL and MSLR scores are potential predictors of mortality in COVID-19 patients within 30 days in a resource-limited country.</p>\",\"PeriodicalId\":19852,\"journal\":{\"name\":\"Pathophysiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2023-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443272/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pathophysiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/pathophysiology30030025\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathophysiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/pathophysiology30030025","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

COVID-19患者的死亡率让世界感到震惊。已经开发了许多评分系统来预测COVID-19患者的死亡率,但一些评分组件无法在有限的卫生设施中进行。在本文中,作者试图创建一个新的简单的评分系统,包括平均动脉压(MAP)、PF比率或SF比率-呼吸率(SF比率-r)和淋巴细胞绝对值(缩写为MPL或MSLR功能),作为COVID-19患者30天内死亡率的预测评分系统。在2021年3月至11月期间住院的132例COVID-19患者中,我们对96例患者进行了随访。我们提出了双变量和多变量分析,以及曲线下面积(AUC)和Kaplan-Meier图。96例患者MPL评分为3分:MAP < 75 mmHg, PF Ratio < 200,淋巴细胞绝对值< 1500/µL; MSLR评分为6分:MAP < 75 mmHg, SF Ratio < 200,淋巴细胞绝对值< 1500/µL,呼吸速率24/min。MPL截断点为2,MSLR为4。MPL和MSLR具有相同的敏感性(79.1%)和特异性(75.5%)。MPL和MSLR的AUC值分别为0.802和0.807。MPL≥2和MSLR≥4对30天生存率的预测相似(p < 0.05)。结论:在资源有限的国家,MPL和MSLR评分是COVID-19患者30天内死亡率的潜在预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality.

The mortality of COVID-19 patients has left the world devastated. Many scoring systems have been developed to predict the mortality of COVID-19 patients, but several scoring components cannot be carried out in limited health facilities. Herein, the authors attempted to create a new and easy scoring system involving mean arterial pressure (MAP), PF Ratio, or SF ratio-respiration rate (SF Ratio-R), and lymphocyte absolute, which were abbreviated as MPL or MSLR functioning, as a predictive scoring system for mortality within 30 days for COVID-19 patients. Of 132 patients with COVID-19 hospitalized between March and November 2021, we followed up on 96 patients. We present bivariate and multivariate analyses as well as the area under the curve (AUC) and Kaplan-Meier charts. From 96 patients, we obtained an MPL score of 3 points: MAP < 75 mmHg, PF Ratio < 200, and lymphocyte absolute < 1500/µL, whereas the MSLR score was 6 points: MAP < 75 mmHg, SF Ratio < 200, lymphocyte absolute < 1500/µL, and respiration rate 24/min. The MPL cut-off point is 2, while the MSLR is 4. MPL and MSLR have the same sensitivity (79.1%) and specificity (75.5%). The AUC value of MPL vs. MSLR was 0.802 vs. 0.807. The MPL ≥ 2 and MSLR ≥ 4 revealed similar predictions for survival within 30 days (p < 0.05). Conclusion: MPL and MSLR scores are potential predictors of mortality in COVID-19 patients within 30 days in a resource-limited country.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Pathophysiology
Pathophysiology Medicine-Pathology and Forensic Medicine
CiteScore
3.10
自引率
0.00%
发文量
48
期刊介绍: Pathophysiology is an international journal which publishes papers in English which address the etiology, development, and elimination of pathological processes. Contributions on the basic mechanisms underlying these processes, model systems and interdisciplinary approaches are strongly encouraged.
期刊最新文献
ITIH4 in Rheumatoid Arthritis Pathogenesis: Network Pharmacology and Molecular Docking Analysis Identify CXCR4 as a Potential Receptor. Pregnancy-Associated Plasma Protein-A and Free β-Human Chorionic Gonadotrophin in Relation with Oxidative Stress in Obese Pregnant Women: A Clinical Cross-Sectional Study. Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient. Advances in Cathepsin S Inhibition: Challenges and Breakthroughs in Drug Development. Evaluation of Full Thickness Wounds Following Application of a Visco-Liquid Hemostat in a Swine Model.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1