Michaela Kendall Bártů, Kristýna Němejcová, Romana Michálková, Quang Hiep Bui, Jana Drozenová, Pavel Fabian, Oluwole Fadare, Jitka Hausnerová, Jan Laco, Radoslav Matěj, Gábor Méhes, Adam Šafanda, Naveena Singh, Petr Škapa, Zuzana Špůrková, Simona Stolnicu, Marián Švajdler, Sigurd F Lax, W Glenn McCluggage, Pavel Dundr
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The cohort consisted of 551 primary ovarian tumors, including serous borderline tumors, low-grade serous carcinomas, high-grade serous carcinomas (HGSC), clear cell carcinomas, endometroid carcinomas, mucinous borderline tumors, and mucinous carcinomas. Immunohistochemical analysis was performed using antibodies against INSM1, synaptophysin, chromogranin, and CD56 on tissue microarray. Positivity for INSM1, synaptophysin, chromogranin, and CD56 was most frequently observed in mucinous tumors (48.7%, 26.0%, 41.5%, and 100%, respectively). The positivity for these NE markers was mostly restricted to nonmucinous elements distributed throughout the tumor. The mucinous borderline tumor and mucinous carcinomas groups had similar proportions of positivity (mucinous borderline tumor: 53%, mucinous carcinomas: 39%). In the other tumor types, except for HGSC, there was only focal expression (5%-10%) or negativity for NE markers. HGSC showed high CD56 expression (in 26% of cases). Survival analysis was only performed for CD56 in HGSC as this was the only group with sufficient positive cases, and it showed no prognostic significance. Except for mucinous tumors, expression of NE markers in non-NE ovarian epithelial tumors is low. 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引用次数: 0
摘要
神经内分泌(NE)标记物在原发性卵巢非NE上皮性肿瘤中的表达很少得到评估。我们的研究旨在评估这些肿瘤中最广泛使用的神经内分泌标记物的表达情况,并确定神经内分泌标记物表达的预后意义。研究对象包括 551 例原发性卵巢肿瘤,包括浆液性边界瘤、低级别浆液性癌、高级别浆液性癌(HGSC)、透明细胞癌、子宫内膜癌、粘液性边界瘤和粘液腺癌。在组织芯片上使用 INSM1、突触素、嗜铬粒蛋白和 CD56 抗体进行免疫组化分析。INSM1、突触素、嗜铬粒蛋白和CD56的阳性率在粘液腺癌中最高(分别为48.7%、26.0%、41.5%和100%)。这些 NE 标记物的阳性大多局限于分布在肿瘤各处的非黏液成分。粘液性边界瘤和粘液腺癌组的阳性比例相似(粘液性边界瘤:53%;粘液腺癌:39%)。在其他类型的肿瘤中,除间皮瘤外,NE标记物仅有局灶性表达(5%-10%)或阴性。HGSC表现出较高的CD56表达(26%的病例)。只对 HGSC 中的 CD56 进行了生存分析,因为只有这一组有足够多的阳性病例,而且没有显示出预后意义。除粘液性肿瘤外,非 NE 卵巢上皮肿瘤中 NE 标记物的表达量较低。CD56 在 HGSC 中经常表达,但没有诊断或预后价值。
Neuroendocrine Marker Expression in Primary Non-neuroendocrine Epithelial Tumors of the Ovary: A Study of 551 Cases.
Expression of neuroendocrine (NE) markers in primary ovarian non-NE epithelial tumors has rarely been evaluated. The aim of our study was to evaluate the expression of the most widely used NE markers in these neoplasms and to determine any prognostic significance of NE marker expression. The cohort consisted of 551 primary ovarian tumors, including serous borderline tumors, low-grade serous carcinomas, high-grade serous carcinomas (HGSC), clear cell carcinomas, endometroid carcinomas, mucinous borderline tumors, and mucinous carcinomas. Immunohistochemical analysis was performed using antibodies against INSM1, synaptophysin, chromogranin, and CD56 on tissue microarray. Positivity for INSM1, synaptophysin, chromogranin, and CD56 was most frequently observed in mucinous tumors (48.7%, 26.0%, 41.5%, and 100%, respectively). The positivity for these NE markers was mostly restricted to nonmucinous elements distributed throughout the tumor. The mucinous borderline tumor and mucinous carcinomas groups had similar proportions of positivity (mucinous borderline tumor: 53%, mucinous carcinomas: 39%). In the other tumor types, except for HGSC, there was only focal expression (5%-10%) or negativity for NE markers. HGSC showed high CD56 expression (in 26% of cases). Survival analysis was only performed for CD56 in HGSC as this was the only group with sufficient positive cases, and it showed no prognostic significance. Except for mucinous tumors, expression of NE markers in non-NE ovarian epithelial tumors is low. CD56 expression in HGSC occurs frequently but is without diagnostic or prognostic value.
期刊介绍:
International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.