对瑞士小鼠28天重复剂量的光紫草叶精油对各种生物参数的口服毒性评估。

IF 2.3 4区 医学 Q3 ENVIRONMENTAL SCIENCES Journal of Toxicology and Environmental Health-Part A-Current Issues Pub Date : 2023-10-02 Epub Date: 2023-08-11 DOI:10.1080/15287394.2023.2246497
Wêndeo Kennedy Costa, Matheus Ferreira Do Nascimento, Valquíria Bruna Guimarães Silva, Bruno Vinicius Souza da Silva, Thiago Henrique Napoleão, Maria Tereza Dos Santos Correia, Márcia Vanusa da Silva, Alisson Macário de Oliveira
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引用次数: 0

摘要

在Psidium L.属的许多重要药用物种中,只有一小部分进行了安全性评估。据报道,原产于巴西的Psidium glaziovianum具有镇痛和抗炎作用;然而,没有明显的报告表明重复给药后的长期安全性。本研究的目的是检查在250、500或1000剂量下28天口服治疗的效果 毫克/千克光子兰精油(PgEO)对雄性和雌性瑞士小鼠行为和生理参数的影响。首先,采用气相色谱-质谱联用技术对PgEO进行了化学表征。检查了以下参数:运动活动、体温、血糖、尿液、血液学、生物化学、组织学和氧化应激。PgEO的特征揭示了48种成分,主要由倍半萜1,8-cineol(24.29%)、α-蒎烯(19.73%)和β-蒎ne(17.31%)组成。数据显示,PgEO处理小鼠可提高抗氧化酶超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的活性,而不会显著影响体重、血液学或生化参数,以及水或食物的消耗。PgEO的重复日剂量给药超过28 天并没有显著改变探索或运动活动。根据我们的研究结果,PgEO每天给药28天 天,表现出低毒性并且对神经系统没有影响。数据表明,PgEO具有降血糖和抗氧化作用,需要在安全评估中予以考虑。
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Evaluation of 28-day repeated doses oral toxicity of essential oil from Psidium glaziovianum Kiaersk leaves on various biological parameters in Swiss mice.

Only a small number of the many medicinally important species in the genus Psidium L. have had their safety assessed. Psidium glaziovianum, a plant native to Brazil, is reported to exert antinociceptive and anti-inflammatory effects; however, there are no apparent reports of long-term safety following administering of repeated doses. The aim of this study was to examine the effects of 28-day oral of treatment at 250, 500 or 1,000 mg/kg Psidium glaziovianum essential oil (PgEO) on behavioral and physiological parameters in male and female Swiss mice. First, PgEO was chemically characterized by gas chromatography mass spectrometry (GC-MS). The following parameters were examined: motor activity, body temperature, blood glucose, urine, hematology, biochemistry, histology, and oxidative stress. Characterization of PgEO revealed 48 components which were dominated by sesquiterpenes 1,8-cineol (24.29%), α-pinene (19.73%) and β-pinene (17.31%). Data showed that PgEO treatment in mice increased activities of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) without markedly affecting body weight, hematological or biochemical parameters, as well as water or food consumption. Administration of PgEO in repeated daily dosages over 28 days did not significantly alter exploratory or locomotor activities. Based upon our findings, PgEO administration daily for 28 days, exhibited low toxicity and absence of effects on the nervous system. Data demonstrated that PgEO produced hypoglycemic and antioxidant actions which need to be considered in safety assessment.

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来源期刊
CiteScore
5.20
自引率
19.20%
发文量
46
审稿时长
8-16 weeks
期刊介绍: The Journal of Toxicology and Environmental Health, Part A , Current Issues is an authoritative journal that features strictly refereed original research in the field of environmental sciences, public and occupational health, and toxicology.
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