Bhaskar Jyoti Saikia , Juhi Bhardwaj , Sangita Paul , Srishti Sharma , Anindita Neog , Swaraj Ranjan Paul , Binukumar BK
{"title":"了解线粒体microRNAs (MitomiRs)在神经退行性疾病中的作用和调控:现状和进展","authors":"Bhaskar Jyoti Saikia , Juhi Bhardwaj , Sangita Paul , Srishti Sharma , Anindita Neog , Swaraj Ranjan Paul , Binukumar BK","doi":"10.1016/j.mad.2023.111838","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span><span><span>MicroRNAs (miRNA) are a class of small non-coding RNA, roughly 21–22 </span>nucleotides in length, which are master </span>gene regulators<span>. These miRNAs bind to the mRNA's 3’ - untranslated region<span> and regulate post-transcriptional gene regulation, thereby influencing various physiological and cellular processes. Another class of miRNAs known as mitochondrial miRNA (MitomiRs) has been found to either originate from the mitochondrial genome or be translocated directly into the mitochondria. Although the role of nuclear DNA encoded miRNA in the progression of various </span></span></span>neurological diseases such as </span>Parkinson's disease, Alzheimer’s disease, </span>Huntington's disease<span><span>, etc. is well known, accumulating evidence suggests the possible role of deregulated mitomiRs in the progression of various neurodegenerative diseases with unknown mechanism. We have attempted to outline the current state of mitomiRs role in controlling </span>mitochondrial gene expression and function through this review, paying particular attention to their contribution to neurological processes, their etiology, and their potential therapeutic use.</span></p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances\",\"authors\":\"Bhaskar Jyoti Saikia , Juhi Bhardwaj , Sangita Paul , Srishti Sharma , Anindita Neog , Swaraj Ranjan Paul , Binukumar BK\",\"doi\":\"10.1016/j.mad.2023.111838\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span><span><span>MicroRNAs (miRNA) are a class of small non-coding RNA, roughly 21–22 </span>nucleotides in length, which are master </span>gene regulators<span>. These miRNAs bind to the mRNA's 3’ - untranslated region<span> and regulate post-transcriptional gene regulation, thereby influencing various physiological and cellular processes. Another class of miRNAs known as mitochondrial miRNA (MitomiRs) has been found to either originate from the mitochondrial genome or be translocated directly into the mitochondria. Although the role of nuclear DNA encoded miRNA in the progression of various </span></span></span>neurological diseases such as </span>Parkinson's disease, Alzheimer’s disease, </span>Huntington's disease<span><span>, etc. is well known, accumulating evidence suggests the possible role of deregulated mitomiRs in the progression of various neurodegenerative diseases with unknown mechanism. We have attempted to outline the current state of mitomiRs role in controlling </span>mitochondrial gene expression and function through this review, paying particular attention to their contribution to neurological processes, their etiology, and their potential therapeutic use.</span></p></div>\",\"PeriodicalId\":18340,\"journal\":{\"name\":\"Mechanisms of Ageing and Development\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mechanisms of Ageing and Development\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0047637423000647\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mechanisms of Ageing and Development","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0047637423000647","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances
MicroRNAs (miRNA) are a class of small non-coding RNA, roughly 21–22 nucleotides in length, which are master gene regulators. These miRNAs bind to the mRNA's 3’ - untranslated region and regulate post-transcriptional gene regulation, thereby influencing various physiological and cellular processes. Another class of miRNAs known as mitochondrial miRNA (MitomiRs) has been found to either originate from the mitochondrial genome or be translocated directly into the mitochondria. Although the role of nuclear DNA encoded miRNA in the progression of various neurological diseases such as Parkinson's disease, Alzheimer’s disease, Huntington's disease, etc. is well known, accumulating evidence suggests the possible role of deregulated mitomiRs in the progression of various neurodegenerative diseases with unknown mechanism. We have attempted to outline the current state of mitomiRs role in controlling mitochondrial gene expression and function through this review, paying particular attention to their contribution to neurological processes, their etiology, and their potential therapeutic use.
期刊介绍:
Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms.
Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.