用于药物测试的体外皮肤芯片模型的最新进展。

IF 3.9 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Opinion on Drug Metabolism & Toxicology Pub Date : 2023-01-01 DOI:10.1080/17425255.2023.2227379
Jong Hwan Sung, Jae Jung Kim
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引用次数: 1

摘要

皮肤是人体表面积最大的器官,是人体抵御外界环境的屏障。在提供保护的同时,它还与身体的其他器官相互作用,并对各种疾病产生影响。在研究这些疾病的背景下,建立生理上真实的全身皮肤体外模型是非常重要的,并且将成为制药、化妆品和食品工业的一个有价值的工具。涵盖领域:这篇文章概述了皮肤结构、生理、以及皮肤中的药物代谢和皮肤病。我们总结了目前可用的各种体外皮肤模型,以及基于器官芯片技术的新型体外模型。我们还解释了多器官芯片的概念,并描述了该领域的最新发展,旨在概括皮肤与身体其他器官的相互作用。专家意见:器官芯片领域的最新发展使体外模型系统的发展比传统模型更接近人类皮肤。在不久的将来,我们将看到各种各样的模型系统,使研究人员能够以更机械的方式研究复杂的疾病,这将有助于开发针对此类疾病的新药。
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Recent advances in in vitro skin-on-a-chip models for drug testing.

Introduction: The skin is an organ that has the largest surface area and provides a barrier against external environment. While providing protection, it also interacts with other organs in the body and has implications for various diseases. Development of physiologically realistic in vitro models of the skin in the context of the whole body is important for studying these diseases and will be a valuable tool for pharmaceutical, cosmetics, and food industry.

Area covered: This article provides an overview of the skin structure, physiology, as well as drug metabolism in the skin, and dermatological diseases. We summarize various in vitro skin models currently available, as well as novel in vitro models based on organ-on-a-chip technology. We also explain the concept of multi-organ-on-a-chip and describe recent developments in this field aimed at recapitulating the interaction of the skin with other organs in the body.

Expert opinion: Recent developments in the organ-on-a-chip field have enabled the development of in vitro model systems that resemble human skin more closely than conventional models. In the near future, we will be seeing various model systems that allow researchers to study complex diseases in a more mechanistic manner, which will help the development of new pharmaceuticals for such diseases.

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来源期刊
Expert Opinion on Drug Metabolism & Toxicology
Expert Opinion on Drug Metabolism & Toxicology 医学-生化与分子生物学
CiteScore
7.90
自引率
2.30%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Expert Opinion on Drug Metabolism & Toxicology (ISSN 1742-5255 [print], 1744-7607 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on all aspects of ADME-Tox. Each article is structured to incorporate the author’s own expert opinion on the scope for future development. The Editors welcome: Reviews covering metabolic, pharmacokinetic and toxicological issues relating to specific drugs, drug-drug interactions, drug classes or their use in specific populations; issues relating to enzymes involved in the metabolism, disposition and excretion of drugs; techniques involved in the study of drug metabolism and toxicology; novel technologies for obtaining ADME-Tox data. Drug Evaluations reviewing the clinical, toxicological and pharmacokinetic data on a particular drug. The audience consists of scientists and managers in the pharmaceutical industry, pharmacologists, clinical toxicologists and related professionals.
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