马颗粒细胞肿瘤的免疫组织化学标记物:一项初步研究。

Q3 Veterinary Journal of Equine Science Pub Date : 2023-06-01 DOI:10.1294/jes.34.37
Aurelia Dolin, Peter Schweiger, Martin Waselau, Monika Egerbacher, Ingrid Walter
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引用次数: 0

摘要

性索间质肿瘤(SCSTs),通常被称为马科动物的颗粒细胞瘤(gct)或颗粒-膜细胞瘤(GTCTs),具有复杂的组成和数量可变的激素分泌细胞。这些肿瘤很难诊断,尤其是在早期阶段。因此,我们在一匹13岁母马的左卵巢内的葡萄柚大小的马GCT上测试了一组抗体,包括vimentin、平滑肌肌动蛋白、层粘连蛋白、Ki-67、e -钙粘蛋白、calretinin、moesin、p-ezrin、AMH和芳香酶,这些标记物用于人类SCSTs的肿瘤组成、分类、进展和预后,该母马的行为与种马相似,睾丸激素水平高于正常卵巢组织。肿瘤增殖率低,颗粒细胞moesin和p-ezrin染色明显。e -钙粘蛋白、calretinin、芳香化酶和AMH被认为是马SCSTs不同细胞成分的潜在标记物,可以支持肿瘤的诊断和分类。
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Immunohistochemical markers for equine granulosa cell tumors: a pilot study.

Sex cord-stromal tumors (SCSTs), generally referred to as granulosa cell tumors (GCTs) or granulosa-theca cell tumors (GTCTs) in equids, show complex compositions and variable numbers of hormone-producing cells. These tumors can be difficult to diagnose, especially in early stages. Therefore, we tested a panel of antibodies for vimentin, smooth muscle actin, laminin, Ki-67, E-cadherin, calretinin, moesin, p-ezrin, AMH, and aromatase, markers used for tumor composition and classification, progression, and prognosis in human SCSTs, on an exemplary grapefruit-size equine GCT within the left ovary of a 13-year-old mare with stallion-like behavior and elevated testosterone levels in comparison with normal ovarian tissue. The tumor showed a low proliferation rate and prominent moesin and p-ezrin staining in granulosa cells. E-cadherin, calretinin, aromatase, and AMH are suggested to be potential markers for different cell components of equine SCSTs that can support tumor diagnosis and classification.

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来源期刊
Journal of Equine Science
Journal of Equine Science Veterinary-Equine
CiteScore
1.60
自引率
0.00%
发文量
9
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