CASM中TECPR1和ATG16L1的独立轴。

IF 14.6 1区生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2024-01-01 Epub Date: 2023-09-07 DOI:10.1080/15548627.2023.2255462

Namrita Kaur, Sven R Carlsson, Alf Håkon Lystad

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引用次数: 0

摘要

ATG8与单膜（CASM）的结合是一个基本的细胞过程，需要哺乳动物ATG8同源物（此处称为ATG8）与内溶酶体区室上的磷脂酰乙醇胺（PE）和磷脂酰丝氨酸（PS）的结合。我们目前的研究，加上Randow、Wu和Wileman实验室最近的报告，揭示了这一过程的另一层。我们发现，除了含有ATG16L1的复合物外，含有TECPR1（含有1的构造蛋白β-螺旋桨重复序列）的ATG12-ATG5 E3复合物也可以促进CASM，从而对该途径有更广泛的了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The separate axes of TECPR1 and ATG16L1 in CASM.

Conjugation of ATG8 to single membranes (CASM) is a fundamental cellular process that entails the conjugation of mammalian Atg8 homologs, here referred to as ATG8, to phosphatidylethanolamine (PE) and phosphatidylserine (PS) on endolysosomal compartments. Our current research, together with recent reports from the Randow, Wu, and Wileman labs, has uncovered yet another layer to this process. We discovered that, in addition to ATG16L1-containing complexes, TECPR1 (tectonin beta-propeller repeat containing 1)-containing ATG12-ATG5 E3 complexes can facilitate CASM, thereby providing a broader understanding of this pathway.

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.