Xingtao Zhao, Xinyan Xue, Zhifu Cui, Felix Kwame Amevor, Yan Wan, Ke Fu, Cheng Wang, Cheng Peng, Yunxia Li
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引用次数: 2
摘要
肝纤维化是一个过度细胞外基质(ECM)聚集和血管生成的过程，最终发展为肝硬化和肝细胞癌(HCC)。随着肝纤维化压力的增加，新的治疗方法需要引起人们的重视。外泌体装载的microRNAs (miRNAs)是肝纤维化模式精确的新兴方法。在这篇综述中，我们概述了不同类型的肝细胞来源的mirna，这些mirna驱动肝纤维化中具有不同生理和病理过程的细胞内/细胞外相互作用通讯。具体来说，我们强调了与免疫反应和血管生成相关的肝纤维化发病机制。此外，本文还综述了肝纤维化潜在的临床生物标志物和基于干细胞移植来源的mirnas的不同治疗策略。基于mirna的方法可能帮助研究人员设计出无细胞肝纤维化治疗的新候选药物。本文分类为:RNA in Disease and Development > RNA in Disease。
microRNAs-based diagnostic and therapeutic applications in liver fibrosis.
Liver fibrosis is a process of over-extracellular matrix (ECM) aggregation and angiogenesis, which develops into cirrhosis and hepatocellular carcinoma (HCC). With the increasing pressure of liver fibrosis, new therapeutics to cure this disease requires much attention. Exosome-cargoed microRNAs (miRNAs) are emerging approaches in the precision of the liver fibrotic paradigm. In this review, we outlined the different types of hepatic cells derived miRNAs that drive intra-/extra-cellular interactive communication in liver fibrosis with different physiological and pathological processes. Specifically, we highlighted the possible mechanism of liver fibrosis pathogenesis associated with immune response and angiogenesis. In addition, potential clinical biomarkers and different stem cell transplant-derived miRNAs-based therapeutic strategies in liver fibrosis were summarized in this review. miRNAs-based approaches might help researchers devise new candidates for the cell-free treatment of liver fibrosis. This article is categorized under: RNA in Disease and Development > RNA in Disease.
期刊介绍：
WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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