主动脉流量与衰老和运动能力有关。

European Heart Journal Open Pub Date : 2023-08-26 eCollection Date: 2023-07-01 DOI:10.1093/ehjopen/oead079
Xiaodan Zhao, Pankaj Garg, Hosamadin Assadi, Ru-San Tan, Ping Chai, Tee Joo Yeo, Gareth Matthews, Zia Mehmood, Shuang Leng, Jennifer Ann Bryant, Lynette L S Teo, Ching Ching Ong, James W Yip, Ju Le Tan, Rob J van der Geest, Liang Zhong
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引用次数: 0

摘要

目的:主动脉血流偏心率的增加与主动脉(AO)病理学有关,但尚未研究其与运动能力的关系。本研究旨在评估健康受试者队列中二维(2D)相位对比(PC)心血管磁共振(CMR)成像得出的流量离心率参数与衰老和心肺运动试验(CPET)之间的关系。方法和结果:在一项前瞻性研究(NCT03217240)中,招募了169名无心血管疾病的健康受试者(年龄44±13岁,男/女:96/73),并在一周内接受了CMR,包括在窦房结正上方的正交平面上的2D PC和CPET(周期测力计)。导出了以下AO流量参数:以体表面积(FFi,BFi)、收缩期平均流量(FDsavg)、收缩期晚期(FDlsavg)、舒张期(FDdavg)、收缩期逆行流量(SRF)、收缩期血流逆转率(sFRR)和脉搏波速度(PWV)为指标的AO正向和反向流量。通过CPET的峰值摄氧量(PVO2)来评估运动能力。FDsavg、FDlsavg、FDdavg、SRF、sFRR和PWV的平均值分别为17±6%、19±8%、29±7%、4.4±4.2 mL、5.9±5.1%和4.3±1.6 m/s。它们都随着年龄的增长而增加(r=0.623,0.628,0.353,0.590,0.649,0.598,均P<0.0001),并随着PVO2的增加而降低(r=-0.302,-0.270,-0.253,-0.149,-0.219,-0.161,均P<0.05),FDsavg在区分具有高风险运动能力的健康受试者(PVO2≤14 mL/kg/min)。结论:AO血流动力学随年龄增长而变化,可预测运动能力。注册号:NCT03217240。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Aortic flow is associated with aging and exercise capacity.

Aims: Increased blood flow eccentricity in the aorta has been associated with aortic (AO) pathology, however, its association with exercise capacity has not been investigated. This study aimed to assess the relationships between flow eccentricity parameters derived from 2-dimensional (2D) phase-contrast (PC) cardiovascular magnetic resonance (CMR) imaging and aging and cardiopulmonary exercise test (CPET) in a cohort of healthy subjects.

Methods and results: One hundred and sixty-nine healthy subjects (age 44 ± 13 years, M/F: 96/73) free of cardiovascular disease were recruited in a prospective study (NCT03217240) and underwent CMR, including 2D PC at an orthogonal plane just above the sinotubular junction, and CPET (cycle ergometer) within one week. The following AO flow parameters were derived: AO forward and backward flow indexed to body surface area (FFi, BFi), average flow displacement during systole (FDsavg), late systole (FDlsavg), diastole (FDdavg), systolic retrograde flow (SRF), systolic flow reversal ratio (sFRR), and pulse wave velocity (PWV). Exercise capacity was assessed by peak oxygen uptake (PVO2) from CPET. The mean values of FDsavg, FDlsavg, FDdavg, SRF, sFRR, and PWV were 17 ± 6%, 19 ± 8%, 29 ± 7%, 4.4 ± 4.2 mL, 5.9 ± 5.1%, and 4.3 ± 1.6 m/s, respectively. They all increased with age (r = 0.623, 0.628, 0.353, 0.590, 0.649, 0.598, all P < 0.0001), and decreased with PVO2 (r = -0.302, -0.270, -0.253, -0.149, -0.219, -0.161, all P < 0.05). A stepwise multivariable linear regression analysis using left ventricular ejection fraction (LVEF), FFi, and FDsavg showed an area under the curve of 0.769 in differentiating healthy subjects with high-risk exercise capacity (PVO2 ≤ 14 mL/kg/min).

Conclusion: AO flow haemodynamics change with aging and predict exercise capacity.

Registration: NCT03217240.

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