SARS-CoV-2 mRNA疫苗在青少年中引发针对组粒变异的持续T细胞反应

IF 4.3 4区 医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2023-08-01 DOI:10.4110/in.2023.23.e33
Sujin Choi, Sang-Hoon Kim, Mi Seon Han, Yoonsun Yoon, Yun-Kyung Kim, Hye-Kyung Cho, Ki Wook Yun, Seung Ha Song, Bin Ahn, Ye Kyung Kim, Sung Hwan Choi, Young June Choe, Heeji Lim, Eun Bee Choi, Kwangwook Kim, Seokhwan Hyeon, Hye Jung Lim, Byung-Chul Kim, Yoo-Kyoung Lee, Eun Hwa Choi, Eui-Cheol Shin, Hyunju Lee
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摘要

严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)疫苗接种已被公认为预防感染和住院的有效手段。然而,高度传染性SARS-CoV-2关注变体(VOCs)的出现导致儿童和青少年感染的大幅增加。在这一人群中,疫苗诱导的免疫和寿命尚未得到很好的定义。因此,我们旨在分析健康青少年接种两次BNT162b2疫苗后对祖先和SARS-CoV-2变体的体液和细胞免疫反应。尽管疫苗接种诱导了针对祖先和SARS-CoV-2变体的刺特异性结合抗体和中和抗体的显著增加,但针对Omicron变体的中和活性明显较低。相反,疫苗诱导的记忆CD4+ T细胞对祖先和Omicron刺突蛋白均表现出实质性的应答。值得注意的是,在两次接种BNT162b2疫苗后3个月,CD4+ T细胞对祖先株和Omicron株的反应都没有减弱。疫苗诱导的记忆T细胞的多功能性也在对Omicron刺突蛋白的反应中得以保留。目前的研究结果描述了在变异/亚变异不断出现的时代,青少年接种疫苗的保护性免疫。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents.

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccine-induced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARS-CoV-2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4+ T cells exhibited substantial responses against both ancestral and Omicron spike proteins. Notably, CD4+ T cell responses against both ancestral and Omicron strains were preserved at 3 months after two shots of the BNT162b2 vaccine without waning. Polyfunctionality of vaccine-induced memory T cells was also preserved in response to Omicron spike protein. The present findings characterize the protective immunity of vaccination for adolescents in the era of continuous emergence of variants/subvariants.

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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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