跨多个组织的儿科表观遗传时钟的评估。

IF 5.7 2区 医学 Q1 Medicine Clinical Epigenetics Pub Date : 2023-09-02 DOI:10.1186/s13148-023-01552-3
Fang Fang, Linran Zhou, Wei Perng, Carmen J Marsit, Anna K Knight, Andres Cardenas, Max T Aung, Marie-France Hivert, Izzuddin M Aris, Jaclyn M Goodrich, Alicia K Smith, Abigail Gaylord, Rebecca C Fry, Emily Oken, George O'Connor, Douglas M Ruden, Leonardo Trasande, Julie B Herbstman, Carlos A Camargo, Nicole R Bush, Anne L Dunlop, Dana M Dabelea, Margaret R Karagas, Carrie V Breton, Carole Ober, Todd M Everson, Grier P Page, Christine Ladd-Acosta
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引用次数: 0

摘要

背景:表观遗传时钟是一种很有前途的评估生物年龄的工具。我们评估了儿童表观遗传时钟在妊娠期和实足年龄测定中的准确性。结果:我们的研究使用了三种DNA甲基化分析微阵列上七种组织类型的数据,发现Knight和Bohlin时钟对血细胞的表现相似,而Lee时钟对胎盘样本的表现更优。儿科-口腔-表观遗传时钟在儿科口腔样本中表现最好,而Horvath时钟被推荐用于儿童血细胞样本。NeoAge时钟以其独特的预测月经后年龄的能力脱颖而出,与婴儿口腔细胞样本中观察到的年龄高度相关。结论:我们的研究结果为未来儿科样本表观遗传时钟的研究和开发提供了有价值的指导,可以更准确地评估生物年龄。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Evaluation of pediatric epigenetic clocks across multiple tissues.

Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.

Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples.

Conclusions: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.

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来源期刊
Clinical Epigenetics
Clinical Epigenetics Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
8.90
自引率
5.30%
发文量
150
审稿时长
12 weeks
期刊介绍: Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.
期刊最新文献
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