乳腺癌转移中基因、分子、细胞和器官之间的关联。

IF 4.2 3区 医学 Q2 ONCOLOGY Clinical & Experimental Metastasis Pub Date : 2024-08-01 Epub Date: 2023-09-09 DOI:10.1007/s10585-023-10230-w
S David Nathanson, Lothar C Dieterich, Xiang H-F Zhang, Dhananjay A Chitale, Lajos Pusztai, Emma Reynaud, Yi-Hsuan Wu, Alejandro Ríos-Hoyo
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引用次数: 0

摘要

本文是基础科学家、病理学家和临床肿瘤学家在亨利-福特健康研讨会上就乳腺癌转移的分子方面的重要性所发表的观点的交叉融合。我们讨论了四个主要议题:(i) 淋巴内皮细胞的复杂作用,以及刺激它们加强淋巴结和全身转移并影响可能抑制转移的抗肿瘤免疫的分子;(ii) 乳腺癌扩散到骨骼时分子和细胞的相互作用,以及骨转移本身如何扩散到内脏;(iii) 乳腺癌的分子表达和形态亚型如何帮助临床医生确定对哪些病人采取更积极或不那么积极的治疗方法;(iv) 乳腺癌寡转移病人的预后与多转移病人的预后有何不同,以及如何证明对这些病人采取积极治疗并有望治愈是合理的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Associations amongst genes, molecules, cells, and organs in breast cancer metastasis.

This paper is a cross fertilization of ideas about the importance of molecular aspects of breast cancer metastasis by basic scientists, a pathologist, and clinical oncologists at the Henry Ford Health symposium. We address four major topics: (i) the complex roles of lymphatic endothelial cells and the molecules that stimulate them to enhance lymph node and systemic metastasis and influence the anti-tumor immunity that might inhibit metastasis; (ii) the interaction of molecules and cells when breast cancer spreads to bone, and how bone metastases may themselves spread to internal viscera; (iii) how molecular expression and morphologic subtypes of breast cancer assist clinicians in determining which patients to treat with more or less aggressive therapies; (iv) how the outcomes of patients with oligometastases in breast cancer are different from those with multiple metastases and how that could justify the aggressive treatment of these patients with the hope of cure.

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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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