TRIM16介导的裂解抑制高糖积累的神经元Aβ。

IF 14.6 1区生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2023-10-01 Epub Date: 2023-07-04 DOI:10.1080/15548627.2023.2229659

Chang Woo Chae, Jee Hyeon Yoon, Jae Ryong Lim, Ji Yong Park, Ji Hyeon Cho, Young Hyun Jung, Gee Euhn Choi, Hyun Jik Lee, Ho Jae Han

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引用次数: 0

摘要

缩写：Aβ：淀粉样蛋白β；AD：阿尔茨海默病；AMPK:5'腺苷一磷酸活化蛋白激酶；CTSB:组织蛋白酶B；CTSD：组织蛋白酶D；DM：糖尿病；ESCRT：运输所需的内体分选复合体；FBXO27:F-box蛋白27；iPSC NDs：诱导多能干细胞衍生的神经元分化细胞；LAMP1：溶酶体相关膜蛋白1；LMP：溶酶体膜透化；LRSAM1：富含亮氨酸重复序列和含有1的无菌α基序；MAP1LC3/LC3：微管相关蛋白1轻链3；MTORC1：雷帕霉素激酶复合物1的机制靶点；p-MAPT/tau：磷酸化微管相关蛋白tau；ROS：活性氧；STZ：链脲佐菌素；TFE3：转录因子E3；TFEB：转录因子EB；TRIM16：包含16个的三元基序；UBE2QL1：泛素偶联酶E2 Q家族样1；VCP：含缬氨酸的蛋白质。

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TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.

Abbreviations: Aβ: amyloid β; AD: Alzheimer disease; AMPK: 5' adenosine monophosphate-activated protein kinase; CTSB: cathepsin B; CTSD: cathepsin D; DM: diabetes mellitus; ESCRT: endosomal sorting complex required for transport; FBXO27: F-box protein 27; iPSC-NDs: induced pluripotent stem cell-derived neuronal differentiated cells; LAMP1: lysosomal-associated membrane protein 1; LMP: lysosomal membrane permeabilization; LRSAM1: leucine rich repeat and sterile alpha motif containing 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTORC1: mechanistic target of rapamycin kinase complex 1; p-MAPT/tau: phosphorylated microtubule associated protein tau; ROS: reactive oxygen species; STZ: streptozotocin; TFE3: transcription factor E3; TFEB: transcription factor EB; TRIM16: tripartite motif containing 16; UBE2QL1: ubiquitin conjugating enzyme E2 Q family like 1; VCP: valosin containing protein.

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.