Walid Q Alali, Naglaa M Abdo, Wadha AlFouzan, Rita Dhar
{"title":"科威特 COVID-19 大流行之前和期间从一家二级医院分离的临床大肠埃希菌和铜绿假单胞菌的抗菌药耐药性模式。","authors":"Walid Q Alali, Naglaa M Abdo, Wadha AlFouzan, Rita Dhar","doi":"10.18683/germs.2022.1341","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The study objective was to compare the prevalence of antimicrobial resistance (AMR) in clinical <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> isolates obtained from a secondary-care hospital prior to and during the COVID-19 pandemic in Kuwait.</p><p><strong>Methods: </strong>A retrospective descriptive study was conducted based on AMR profiles of clinical Escherichia coli and Pseudomonas aeruginosa isolates. The AMR data represented isolates from five specimen types (body fluids; blood; respiratory; wound, bone, or other tissues; and urine) of patients admitted to four wards (surgical, medical, pediatric, and maternal-postnatal). Tested isolates between January 2019 and February 2020 represented the pre-COVID-19 pandemic period in Kuwait, whereas those from February 2020 until April 2021 represented the 'during COVID-19' period.</p><p><strong>Results: </strong>A total of 1,303 isolates (57.2% <i>E. coli</i> and 42.8% <i>P. aeruginosa</i>) were analyzed. For ceftazidime, ertapenem and meropenem, the prevalence of AMR in <i>E. coli</i> was significantly (p<0.05) lower in pre-COVID-19 wards compared to that during COVID-19, whereas for other antibiotics (i.e., cefepime, gentamicin, and trimethoprim/sulfamethoxazole), the prevalence of AMR in pre-COVID-19 was significantly higher than that during COVID-19. The prevalence of AMR to gentamicin in <i>P. aeruginosa</i> isolates from non-COVID-19 wards (52.8%) was significantly higher (p<0.001) than that from COVID-19 wards (35.0%) and from the pre-COVID-19 period (32.9%). The multidrug-resistance (MDR) prevalence was 37.4% for <i>E. coli</i> and 32.1% for <i>P. aeruginosa</i> isolates. The odds of MDR in <i>E. coli</i> isolates from the COVID-19 medical wards were significantly lower (OR=0.27, [95%CI: 0.09-0.80], p=0.018) compared to the pre-COVID-19 wards. The odds of MDR <i>E. coli</i> and <i>P. aeruginosa</i> isolates by COVID-19 status stratified by specimen type were not different (p>0.05).</p><p><strong>Conclusions: </strong>No major differences in AMR in <i>E. coli</i> and <i>P. aeruginosa</i> prevalence by specimen type and wards prior to and during the COVID-19 pandemic was observed at this hospital. The high reported MDR prevalence calls for better infection control and prevention.</p>","PeriodicalId":45107,"journal":{"name":"GERMS","volume":"12 3","pages":"372-383"},"PeriodicalIF":1.7000,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482471/pdf/germs-12-03-372.pdf","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial resistance pattern in clinical <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> isolates obtained from a secondary-care hospital prior to and during the COVID-19 pandemic in Kuwait.\",\"authors\":\"Walid Q Alali, Naglaa M Abdo, Wadha AlFouzan, Rita Dhar\",\"doi\":\"10.18683/germs.2022.1341\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The study objective was to compare the prevalence of antimicrobial resistance (AMR) in clinical <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> isolates obtained from a secondary-care hospital prior to and during the COVID-19 pandemic in Kuwait.</p><p><strong>Methods: </strong>A retrospective descriptive study was conducted based on AMR profiles of clinical Escherichia coli and Pseudomonas aeruginosa isolates. The AMR data represented isolates from five specimen types (body fluids; blood; respiratory; wound, bone, or other tissues; and urine) of patients admitted to four wards (surgical, medical, pediatric, and maternal-postnatal). Tested isolates between January 2019 and February 2020 represented the pre-COVID-19 pandemic period in Kuwait, whereas those from February 2020 until April 2021 represented the 'during COVID-19' period.</p><p><strong>Results: </strong>A total of 1,303 isolates (57.2% <i>E. coli</i> and 42.8% <i>P. aeruginosa</i>) were analyzed. For ceftazidime, ertapenem and meropenem, the prevalence of AMR in <i>E. coli</i> was significantly (p<0.05) lower in pre-COVID-19 wards compared to that during COVID-19, whereas for other antibiotics (i.e., cefepime, gentamicin, and trimethoprim/sulfamethoxazole), the prevalence of AMR in pre-COVID-19 was significantly higher than that during COVID-19. The prevalence of AMR to gentamicin in <i>P. aeruginosa</i> isolates from non-COVID-19 wards (52.8%) was significantly higher (p<0.001) than that from COVID-19 wards (35.0%) and from the pre-COVID-19 period (32.9%). The multidrug-resistance (MDR) prevalence was 37.4% for <i>E. coli</i> and 32.1% for <i>P. aeruginosa</i> isolates. The odds of MDR in <i>E. coli</i> isolates from the COVID-19 medical wards were significantly lower (OR=0.27, [95%CI: 0.09-0.80], p=0.018) compared to the pre-COVID-19 wards. The odds of MDR <i>E. coli</i> and <i>P. aeruginosa</i> isolates by COVID-19 status stratified by specimen type were not different (p>0.05).</p><p><strong>Conclusions: </strong>No major differences in AMR in <i>E. coli</i> and <i>P. aeruginosa</i> prevalence by specimen type and wards prior to and during the COVID-19 pandemic was observed at this hospital. The high reported MDR prevalence calls for better infection control and prevention.</p>\",\"PeriodicalId\":45107,\"journal\":{\"name\":\"GERMS\",\"volume\":\"12 3\",\"pages\":\"372-383\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2022-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482471/pdf/germs-12-03-372.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"GERMS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18683/germs.2022.1341\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/9/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"GERMS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18683/germs.2022.1341","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Antimicrobial resistance pattern in clinical Escherichia coli and Pseudomonas aeruginosa isolates obtained from a secondary-care hospital prior to and during the COVID-19 pandemic in Kuwait.
Introduction: The study objective was to compare the prevalence of antimicrobial resistance (AMR) in clinical Escherichia coli and Pseudomonas aeruginosa isolates obtained from a secondary-care hospital prior to and during the COVID-19 pandemic in Kuwait.
Methods: A retrospective descriptive study was conducted based on AMR profiles of clinical Escherichia coli and Pseudomonas aeruginosa isolates. The AMR data represented isolates from five specimen types (body fluids; blood; respiratory; wound, bone, or other tissues; and urine) of patients admitted to four wards (surgical, medical, pediatric, and maternal-postnatal). Tested isolates between January 2019 and February 2020 represented the pre-COVID-19 pandemic period in Kuwait, whereas those from February 2020 until April 2021 represented the 'during COVID-19' period.
Results: A total of 1,303 isolates (57.2% E. coli and 42.8% P. aeruginosa) were analyzed. For ceftazidime, ertapenem and meropenem, the prevalence of AMR in E. coli was significantly (p<0.05) lower in pre-COVID-19 wards compared to that during COVID-19, whereas for other antibiotics (i.e., cefepime, gentamicin, and trimethoprim/sulfamethoxazole), the prevalence of AMR in pre-COVID-19 was significantly higher than that during COVID-19. The prevalence of AMR to gentamicin in P. aeruginosa isolates from non-COVID-19 wards (52.8%) was significantly higher (p<0.001) than that from COVID-19 wards (35.0%) and from the pre-COVID-19 period (32.9%). The multidrug-resistance (MDR) prevalence was 37.4% for E. coli and 32.1% for P. aeruginosa isolates. The odds of MDR in E. coli isolates from the COVID-19 medical wards were significantly lower (OR=0.27, [95%CI: 0.09-0.80], p=0.018) compared to the pre-COVID-19 wards. The odds of MDR E. coli and P. aeruginosa isolates by COVID-19 status stratified by specimen type were not different (p>0.05).
Conclusions: No major differences in AMR in E. coli and P. aeruginosa prevalence by specimen type and wards prior to and during the COVID-19 pandemic was observed at this hospital. The high reported MDR prevalence calls for better infection control and prevention.