病毒性肺曲霉菌病的护理点检测。

IF 3.9 3区 医学 Q1 PATHOLOGY Expert Review of Molecular Diagnostics Pub Date : 2024-03-01 Epub Date: 2023-09-21 DOI:10.1080/14737159.2023.2257597
Robina Aerts, Brice Autier, Maximilian Gornicec, Juergen Prattes, Katrien Lagrou, Jean-Pierre Gangneux, Martin Hoenigl
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引用次数: 0

摘要

引言:在过去几年中,严重呼吸道病毒感染,特别是由严重急性呼吸综合征冠状病毒2型(严重急性呼吸系统综合征冠状病毒冠状病毒2型)和流感病毒引起的感染,已成为危重患者中病毒相关肺曲霉菌病(VAPA)的风险因素。VAPA诊断延迟与死亡率增加有关。护理点测试可能在VAPA的早期诊断中发挥重要作用,从而改善患者的预后。涵盖的领域:以下综述将提供VAPA护理点测试的最新情况,分析呼吸和血液样本的表现。专家意见:已经出现了护理点测试,特别是IMMY曲霉半乳甘露聚糖侧流分析(LFA)在诊断VAPA方面显示出与半乳甘露聚糖ELISA相当的性能。值得注意的是,几乎所有的VAPA POC测试评估都是在新冠肺炎患者中进行的,流感患者的数据非常有限。对于新冠肺炎相关肺曲霉菌病(CAPA)的早期诊断,LFA在呼吸样本中,特别是在支气管肺泡灌洗液中表现出了良好的表现,从而可能有助于改善患者的预后。相反,血清LFA检测可能对疾病的早期诊断无效,除非是侵袭性气管支气管曲霉菌病。
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Point-of-care testing for viral-associated pulmonary aspergillosis.

Introduction: Over the last years, severe respiratory viral infections, particularly those caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the influenza virus, have emerged as risk factor for viral-associated pulmonary aspergillosis (VAPA) among critically ill patients. Delays in diagnosis of VAPA are associated with increased mortality. Point-of-care-tests may play an important role in earlier diagnosis of VAPA and thus improve patient outcomes.

Areas covered: The following review will give an update on point-of-care tests for VAPA, analyzing performances in respiratory and blood specimens.

Expert opinion: Point-of-care tests have emerged, and particularly the IMMY Aspergillus galactomannan lateral flow assay (LFA) shows performances comparable to the galactomannan ELISA for diagnosis of VAPA. Notably, nearly all evaluations of POC tests for VAPA have been performed in COVID-19 patients, with very limited data in influenza patients. For early diagnosis of COVID associated pulmonary aspergillosis (CAPA), the LFA has shown promising performances in respiratory samples, particularly in bronchoalveolar lavage fluid, and may thereby help in improving patient outcomes. In contrast, serum LFA testing may not be useful for early diagnosis of disease, except in cases with invasive tracheobronchial aspergillosis.

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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
71
审稿时长
1 months
期刊介绍: Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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