用于治疗骨质疏松症的新兴纳米级输送系统。

IF 11.3 1区 医学 Q1 Medicine Biomaterials Research Pub Date : 2023-07-13 DOI:10.1186/s40824-023-00413-7
Anoop Puthiyoth Dayanandan, Woong Jin Cho, Hyemin Kang, Alvin Bacero Bello, Byoung Ju Kim, Yoshie Arai, Soo-Hong Lee
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引用次数: 0

摘要

骨质疏松症是一种病理状态,其特点是骨吸收速度加快,导致骨密度降低,增加骨折的易感性,尤其是在老年人群中。传统的骨质疏松症治疗方法虽然有一定的疗效,但也存在一定的局限性,包括药物生物利用度有限、非特异性给药以及不良反应的发生。近年来,以纳米颗粒为基础的给药系统成为治疗骨质疏松症的一种很有前景的方法。纳米颗粒具有独特的物理化学特性,如体积小、表面积与体积比大、表面特性可调等,这些特性使其能够克服传统疗法的局限性。这些纳米颗粒具有多种优势,包括增强药物稳定性、控制释放动力学、靶向骨组织给药和提高药物生物利用度。本综述旨在深入探讨基于纳米颗粒的骨质疏松症疗法的最新进展。它阐明了在此背景下采用的各种类型的纳米颗粒,包括二氧化硅、聚合物、固体脂质和金属纳米颗粒,以及它们的特定加工技术和固有特性,这些技术和特性使它们成为治疗骨质疏松症的潜在药物载体。此外,本综述还讨论了与纳米颗粒给药系统的开发和临床应用相关的挑战和未来建议。这些挑战包括可扩展性、安全性评估和监管考虑等问题。然而,尽管存在这些挑战,利用基于纳米颗粒的给药系统仍有望通过更有效和更有针对性的疗法彻底改变骨质疏松症治疗领域,最终改善患者的预后。
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Emerging nano-scale delivery systems for the treatment of osteoporosis.

Osteoporosis is a pathological condition characterized by an accelerated bone resorption rate, resulting in decreased bone density and increased susceptibility to fractures, particularly among the elderly population. While conventional treatments for osteoporosis have shown efficacy, they are associated with certain limitations, including limited drug bioavailability, non-specific administration, and the occurrence of adverse effects. In recent years, nanoparticle-based drug delivery systems have emerged as a promising approach for managing osteoporosis. Nanoparticles possess unique physicochemical properties, such as a small size, large surface area-to-volume ratio, and tunable surface characteristics, which enable them to overcome the limitations of conventional therapies. These nanoparticles offer several advantages, including enhanced drug stability, controlled release kinetics, targeted bone tissue delivery, and improved drug bioavailability. This comprehensive review aims to provide insights into the recent advancements in nanoparticle-based therapy for osteoporosis. It elucidates the various types of nanoparticles employed in this context, including silica, polymeric, solid lipid, and metallic nanoparticles, along with their specific processing techniques and inherent properties that render them suitable as potential drug carriers for osteoporosis treatment. Furthermore, this review discusses the challenges and future suggestions associated with the development and translation of nanoparticle drug delivery systems for clinical use. These challenges encompass issues such as scalability, safety assessment, and regulatory considerations. However, despite these challenges, the utilization of nanoparticle-based drug delivery systems holds immense promise in revolutionizing the field of osteoporosis management by enabling more effective and targeted therapies, ultimately leading to improved patient outcomes.

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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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