布洛芬、双氯芬酸、萘普生和对乙酰氨基酚对酸刺激大鼠身体伸展和酸抑制摄食行为的临床前比较

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2022-12-01 DOI:10.1097/FBP.0000000000000704
Ahmad A Altarifi, Bassel A Younis, Khawla Q Nuseir, Arwa A Al-Mousa, Ahmad K Qaoud, Mohammad I Alsalem, John K Neubert
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引用次数: 0

摘要

疼痛是给全世界社会的健康和经济带来负担的一个主要问题。非甾体抗炎药(NSAIDs)是一种非处方药,广泛用于轻度至中度疼痛。在临床上,这类药物的选择主要是根据患者和医生之前的经验。在此,我们研究了最常用的非甾体抗炎药和对乙酰氨基酚在炎症性疼痛大鼠模型中的治疗效果差异。腹腔注射乳酸后,评估小鼠的身体伸展和进食行为。最初,在两种行为模型中,对成年雄性大鼠进行了不同浓度的乳酸评估。选取浓度为1.8和3.2%的酸分别评价布洛芬、双氯芬酸、萘普生和对乙酰氨基酚对身体伸展和摄食行为的影响。在饲喂研究中,首先评估饲喂研究前1-24 h的限食时间,并选择24 h进行进一步试验。对乙酰氨基酚(100 mg/kg)、双氯芬酸(10 mg/kg)、布洛芬(10-32 mg/kg)和萘普生(3.2-10 mg/kg)显著降低酸刺激下的身体伸展。同样,对乙酰氨基酚(100 mg/kg)、双氯芬酸(10 mg/kg)和布洛芬(32 mg/kg)在3.2%乳酸后显著增加了食物消耗。不同试验药物对拉伸和摄食行为的影响均无显著差异。总之,在临床前研究中,摄食行为对疼痛和镇痛药物提供了很好的评价。在乳酸刺激的身体伸展和抑郁的进食行为中,所有测试药物的效果都是相似的。
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Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats.

Pain is a major problem that burdens the health and economy of societies worldwide. Nonsteroidal anti-inflammatory drugs (NSAIDs) are over-the-counter medications that are widely indicated for mild to moderate pain conditions. Clinically, the selection of a medication among this class is mainly based according to both patient's and doctor's previous experiences. Herein, we studied differences in therapeutic efficacies among the most commonly prescribed NSAIDs and acetaminophen in inflammatory pain rat model. Body stretching and food consumption behaviors were assessed after intraperitoneal administration of lactic acid. Initially, different concentrations of lactic acid were evaluated in adult male rats in both behavioral models. Acid concentrations of 1.8 and 3.2% were selected to assess the effects of ibuprofen, diclofenac, naproxen, and acetaminophen in body stretching and feeding behaviors, respectively. In the feeding study, food restriction for 1-24 h prior to feeding studies was assessed at first, and 24 h was selected for further tests. Acetaminophen (100 mg/kg), diclofenac (10 mg/kg), ibuprofen (10-32 mg/kg), and naproxen (3.2-10 mg/kg) significantly decreased acid-stimulated body stretching. Likewise, acetaminophen (100 mg/kg), diclofenac (10 mg/kg), and ibuprofen (32 mg/kg) increased food consumption significantly after 3.2% lactic acid. There were no significant differences between different test drugs efficacies in both stretching and feeding behaviors. In conclusion, feeding behavior provides a good appraisal for pain and analgesic drugs in preclinical studies. There were comparable efficacies between all tested medications in both lactic acid-stimulated body stretching and -depressed feeding behaviors.

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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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