Bassel H. Al Wattar (Consultant Obstetrician and Gynaecologist) , Vikram Talaulikar (Associate Specialist in Reproductive Medicine & Hon Associate Professor in Women's Health)
{"title":"以非雌激素为基础的更年期辅助疗法","authors":"Bassel H. Al Wattar (Consultant Obstetrician and Gynaecologist) , Vikram Talaulikar (Associate Specialist in Reproductive Medicine & Hon Associate Professor in Women's Health)","doi":"10.1016/j.beem.2023.101819","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Women are living a significant portion of their adult lives in the post-reproductive phase, and many seek help for debilitating menopausal symptoms. Every individual’s experience of </span>menopausal transition<span><span> is unique. Adopting a holistic approach to managing the menopause using a combination of lifestyle, hormonal, and non-hormonal interventions is key to maximise the quality of life of affected women. However, many opt to use non hormonal options or have contraindications to using hormonal therapy. Studies have shown that several pharmacological non-hormonal medications such as </span>SSRIs<span>, SSRI/SNRIs, Gabapentin<span>, and Pregabalin are effective for managing </span></span></span></span>vasomotor<span><span> symptoms as well as other menopausal symptoms. Their main side effects are dry mouth<span>, nausea, constipation, reduced libido<span><span>, and loss of appetite. </span>Clonidine is the only non-hormonal </span></span></span>drug<span><span> which is licenced for control of vasomotor symptoms in the UK, but has several side effects including dizziness<span><span> and sleep disturbance. Cognitive Behavioural Therapy is recommended as a </span>treatment for anxiety, sleep problems and vasomotor symptoms related to menopausal transition. Evidence for clinical efficacy and safety of herbal remedies and alternative therapies remains weak. Studies with </span></span>neurokinin receptor 3 antagonists<span> on women with hot flushes have shown improvement in vasomotor symptoms and results of large-scale studies are awaited.</span></span></span></p></div>","PeriodicalId":8810,"journal":{"name":"Best practice & research. Clinical endocrinology & metabolism","volume":null,"pages":null},"PeriodicalIF":6.1000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-oestrogen-based and complementary therapies for menopause\",\"authors\":\"Bassel H. Al Wattar (Consultant Obstetrician and Gynaecologist) , Vikram Talaulikar (Associate Specialist in Reproductive Medicine & Hon Associate Professor in Women's Health)\",\"doi\":\"10.1016/j.beem.2023.101819\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Women are living a significant portion of their adult lives in the post-reproductive phase, and many seek help for debilitating menopausal symptoms. Every individual’s experience of </span>menopausal transition<span><span> is unique. Adopting a holistic approach to managing the menopause using a combination of lifestyle, hormonal, and non-hormonal interventions is key to maximise the quality of life of affected women. However, many opt to use non hormonal options or have contraindications to using hormonal therapy. Studies have shown that several pharmacological non-hormonal medications such as </span>SSRIs<span>, SSRI/SNRIs, Gabapentin<span>, and Pregabalin are effective for managing </span></span></span></span>vasomotor<span><span> symptoms as well as other menopausal symptoms. Their main side effects are dry mouth<span>, nausea, constipation, reduced libido<span><span>, and loss of appetite. </span>Clonidine is the only non-hormonal </span></span></span>drug<span><span> which is licenced for control of vasomotor symptoms in the UK, but has several side effects including dizziness<span><span> and sleep disturbance. Cognitive Behavioural Therapy is recommended as a </span>treatment for anxiety, sleep problems and vasomotor symptoms related to menopausal transition. Evidence for clinical efficacy and safety of herbal remedies and alternative therapies remains weak. Studies with </span></span>neurokinin receptor 3 antagonists<span> on women with hot flushes have shown improvement in vasomotor symptoms and results of large-scale studies are awaited.</span></span></span></p></div>\",\"PeriodicalId\":8810,\"journal\":{\"name\":\"Best practice & research. Clinical endocrinology & metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Best practice & research. Clinical endocrinology & metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1521690X23000933\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Best practice & research. Clinical endocrinology & metabolism","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1521690X23000933","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Non-oestrogen-based and complementary therapies for menopause
Women are living a significant portion of their adult lives in the post-reproductive phase, and many seek help for debilitating menopausal symptoms. Every individual’s experience of menopausal transition is unique. Adopting a holistic approach to managing the menopause using a combination of lifestyle, hormonal, and non-hormonal interventions is key to maximise the quality of life of affected women. However, many opt to use non hormonal options or have contraindications to using hormonal therapy. Studies have shown that several pharmacological non-hormonal medications such as SSRIs, SSRI/SNRIs, Gabapentin, and Pregabalin are effective for managing vasomotor symptoms as well as other menopausal symptoms. Their main side effects are dry mouth, nausea, constipation, reduced libido, and loss of appetite. Clonidine is the only non-hormonal drug which is licenced for control of vasomotor symptoms in the UK, but has several side effects including dizziness and sleep disturbance. Cognitive Behavioural Therapy is recommended as a treatment for anxiety, sleep problems and vasomotor symptoms related to menopausal transition. Evidence for clinical efficacy and safety of herbal remedies and alternative therapies remains weak. Studies with neurokinin receptor 3 antagonists on women with hot flushes have shown improvement in vasomotor symptoms and results of large-scale studies are awaited.
期刊介绍:
Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management.
Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.