全面回顾前列腺癌的最新治疗策略:治疗目标和 SAR。

IF 3.3 3区 医学 Q2 CHEMISTRY, MEDICINAL Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/1389557523666230911141339
Manish Chaudhary, Shubham Kumar, Paranjeet Kaur, Sanjeev Kumar Sahu, Amit Mittal
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引用次数: 0

摘要

前列腺癌是一种影响全球大量人口的疾病。雄激素剥夺疗法(ADT)已成为治疗晚期前列腺癌的基础,被用于从新辅助治疗到转移阶段的大多数临床治疗中。尽管 ADT 能成功控制大多数男性的病情,但激素治疗最终还是会失败。针对各种激素难治性疾病患者开发了新的分子。分子肿瘤学的进步加深了人们对控制前列腺细胞死亡的多种细胞机制的认识,这些认识可以帮助开发出更有效、更耐受的前列腺癌疗法。这篇综述主要介绍了可能对前列腺治疗有帮助的多种疗法,如信号传导抑制剂、疫苗和雄激素受体抑制剂。此外,还重点介绍了各种生物活性分子及其衍生物,它们都是潜在的抗前列腺癌药物。本文还强调了前列腺癌药物化学领域的最新进展。
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Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR.

Prostate cancer is a disease that is affecting a large population worldwide. Androgen deprivation therapy (ADT) has become a foundation for the treatment of advanced prostate cancer, as used in most clinical settings from neo-adjuvant to metastatic stage. In spite of the success of ADT in managing the disease in the majority of men, hormonal manipulation fails eventually. New molecules are developed for patients with various hormone-refractory diseases. Advancements in molecular oncology have increased understanding of numerous cellular mechanisms which control cell death in the prostate and these insights can lead to the development of more efficacious and tolerable therapies for carcinoma of the prostate. This review is focused on numerous therapies that might be a boon for prostate therapy like signaling inhibitors, vaccines, and inhibitors of androgen receptors. Along with these, various bioactive molecules and their derivatives are highlighted, which act as potential antiprostate cancer agents. This article also emphasized the recent advances in the field of medicinal chemistry of prostate cancer agents.

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来源期刊
CiteScore
7.80
自引率
0.00%
发文量
231
审稿时长
6 months
期刊介绍: The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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