非编码RNA在眼睛发育和疾病中的作用。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-09-01 Epub Date: 2023-02-27 DOI:10.1002/wrna.1785
Xinrui Shi, Zhengbo Xue, Kaicheng Ye, Jian Yuan, Yan Zhang, Jia Qu, Jianzhong Su
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引用次数: 1

摘要

眼部疾病的患病率在全球范围内急剧上升,尤其是那些导致视力障碍和永久性视力丧失的疾病,包括白内障、青光眼、年龄相关性黄斑变性和糖尿病视网膜病变。大量证据表明,ncRNA是各种生物发生和生物学功能的关键调节因子,控制眼组织中与组织发生和细胞分化相关的基因表达。ncRNA的异常表达和功能可导致视觉系统功能障碍,并介导眼部疾病的进展。在这里,我们主要概述ncRNA的精确调节在眼病患者眼睛发育和功能中的作用。我们还强调了进行ncRNA研究的挑战和未来前景,特别关注ncRNA的作用,这些作用可能在各种眼病的诊断和治疗应用中具有更大的前景。这篇文章被分类为:调节RNAs/RNAi/核糖开关>疾病和发育中的调节RNAs RNA>疾病中的RNA疾病和发展中的RNA>发育中的RNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Roles of non-coding RNAs in eye development and diseases.

The prevalence of ocular disorders is dramatically increasing worldwide, especially those that cause visual impairment and permanent loss of vision, including cataract, glaucoma, age-related macular degeneration, and diabetic retinopathy. Extensive evidence has shown that ncRNAs are key regulators in various biogenesis and biological functions, controlling gene expression related to histogenesis and cell differentiation in ocular tissues. Aberrant expression and function of ncRNA can lead to dysfunction of visual system and mediate progression of eye disorders. Here, we mainly offer an overview of the role of precise modulation of ncRNAs in eye development and function in patients with eye diseases. We also highlight the challenges and future perspectives in conducting ncRNA studies, focusing specifically on the role of ncRNAs that may hold expanded promise for their diagnostic and therapeutic applications in various eye diseases. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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