{"title":"HPV感染的流行病学特征和传播性：2013-2021年中国福建金三角地区的一项长期回顾性研究。","authors":"Jingwen Xu , Guzainuer Abudurusuli , Jia Rui , Zhuoyang Li , Zeyu Zhao , Yilan Xia , Xiaohao Guo , Buasiyamu Abudunaibi , Benhua Zhao , Qiwei Guo , Jing-An Cui , Yulin Zhou , Tianmu Chen","doi":"10.1016/j.epidem.2023.100707","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Multiple human papillomavirus (HPV)-associated diseases have put a significant disease burden on the world. Therefore, we conducted a study to explore the epidemiological characteristics of HPV and the transmissibility of its genotypes.</p></div><div><h3>Methods</h3><p>HPV testing data was collected from Hospital. A transmission dynamics model of HPV was constructed to simulate and compare the transmissibility of different HPV genotypes, which was quantitatively described by the basic reproduction number (<em>R</em><sub>0</sub>).</p></div><div><h3>Results</h3><p>The collected HPV subjects were mainly from Xiamen City, Zhangzhou City and Quanzhou City, together, they are known as the Hokkien golden triangle. There were variations in the distribution of HPV infections by age groups. Among all HPV genotypes, 13 of them had <em>R</em><sub>0</sub> > 1, with 10 of them being high-risk types. The top five were HPV56, 18, 58, 52 and 53, among which, HPV56, 18, 58 and 42 were of high risk, whereas HPV53 was not, and the <em>R</em><sub>0</sub> values for the five were 3.35 (CI: 0.00–9.99), 3.20 (CI: 0.00–6.46), 3.19 (CI: 1.27–6.94), 3.19 (CI: 1.01–8.42) and 2.99 (CI: 0.00–9.39), respectively. In addition, HPV52 had <em>R</em><sub>0</sub> > 1 for about 51 months, which had the longest duration.</p></div><div><h3>Conclusion</h3><p>Most high-risk HPV types in the Hokkien golden triangle could transmit among the population. Therefore, there is a need of further optimization for developing HPV vaccines and better detection methods in the region.</p></div>","PeriodicalId":49206,"journal":{"name":"Epidemics","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epidemiological characteristics and transmissibility of HPV infection: A long-term retrospective study in Hokkien Golden Triangle, China, 2013–2021\",\"authors\":\"Jingwen Xu , Guzainuer Abudurusuli , Jia Rui , Zhuoyang Li , Zeyu Zhao , Yilan Xia , Xiaohao Guo , Buasiyamu Abudunaibi , Benhua Zhao , Qiwei Guo , Jing-An Cui , Yulin Zhou , Tianmu Chen\",\"doi\":\"10.1016/j.epidem.2023.100707\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Multiple human papillomavirus (HPV)-associated diseases have put a significant disease burden on the world. Therefore, we conducted a study to explore the epidemiological characteristics of HPV and the transmissibility of its genotypes.</p></div><div><h3>Methods</h3><p>HPV testing data was collected from Hospital. A transmission dynamics model of HPV was constructed to simulate and compare the transmissibility of different HPV genotypes, which was quantitatively described by the basic reproduction number (<em>R</em><sub>0</sub>).</p></div><div><h3>Results</h3><p>The collected HPV subjects were mainly from Xiamen City, Zhangzhou City and Quanzhou City, together, they are known as the Hokkien golden triangle. There were variations in the distribution of HPV infections by age groups. Among all HPV genotypes, 13 of them had <em>R</em><sub>0</sub> > 1, with 10 of them being high-risk types. The top five were HPV56, 18, 58, 52 and 53, among which, HPV56, 18, 58 and 42 were of high risk, whereas HPV53 was not, and the <em>R</em><sub>0</sub> values for the five were 3.35 (CI: 0.00–9.99), 3.20 (CI: 0.00–6.46), 3.19 (CI: 1.27–6.94), 3.19 (CI: 1.01–8.42) and 2.99 (CI: 0.00–9.39), respectively. In addition, HPV52 had <em>R</em><sub>0</sub> > 1 for about 51 months, which had the longest duration.</p></div><div><h3>Conclusion</h3><p>Most high-risk HPV types in the Hokkien golden triangle could transmit among the population. Therefore, there is a need of further optimization for developing HPV vaccines and better detection methods in the region.</p></div>\",\"PeriodicalId\":49206,\"journal\":{\"name\":\"Epidemics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epidemics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1755436523000439\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1755436523000439","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Epidemiological characteristics and transmissibility of HPV infection: A long-term retrospective study in Hokkien Golden Triangle, China, 2013–2021
Objective
Multiple human papillomavirus (HPV)-associated diseases have put a significant disease burden on the world. Therefore, we conducted a study to explore the epidemiological characteristics of HPV and the transmissibility of its genotypes.
Methods
HPV testing data was collected from Hospital. A transmission dynamics model of HPV was constructed to simulate and compare the transmissibility of different HPV genotypes, which was quantitatively described by the basic reproduction number (R0).
Results
The collected HPV subjects were mainly from Xiamen City, Zhangzhou City and Quanzhou City, together, they are known as the Hokkien golden triangle. There were variations in the distribution of HPV infections by age groups. Among all HPV genotypes, 13 of them had R0 > 1, with 10 of them being high-risk types. The top five were HPV56, 18, 58, 52 and 53, among which, HPV56, 18, 58 and 42 were of high risk, whereas HPV53 was not, and the R0 values for the five were 3.35 (CI: 0.00–9.99), 3.20 (CI: 0.00–6.46), 3.19 (CI: 1.27–6.94), 3.19 (CI: 1.01–8.42) and 2.99 (CI: 0.00–9.39), respectively. In addition, HPV52 had R0 > 1 for about 51 months, which had the longest duration.
Conclusion
Most high-risk HPV types in the Hokkien golden triangle could transmit among the population. Therefore, there is a need of further optimization for developing HPV vaccines and better detection methods in the region.
期刊介绍：
Epidemics publishes papers on infectious disease dynamics in the broadest sense. Its scope covers both within-host dynamics of infectious agents and dynamics at the population level, particularly the interaction between the two. Areas of emphasis include: spread, transmission, persistence, implications and population dynamics of infectious diseases; population and public health as well as policy aspects of control and prevention; dynamics at the individual level; interaction with the environment, ecology and evolution of infectious diseases, as well as population genetics of infectious agents.
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