油橄榄叶提取物对大鼠顺铂肾毒性模型的改善作用。

IF 1.7 Q3 UROLOGY & NEPHROLOGY International Journal of Nephrology Pub Date : 2023-01-01 DOI:10.1155/2023/2074498
Doa'a Ibrahim, Abdulsalam Halboup, Mohammed Al Ashwal, Amani Shamsher
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引用次数: 0

摘要

背景:油橄榄叶提取物(OELE)具有潜在的健康益处和防止细胞毒性。本研究探讨OELE对顺铂所致大鼠肾毒性的可能改善作用。方法:将大鼠分为6组;两组分别给予150 mg/kg或300 mg/kg OELE,一组在实验第一天给予单剂量顺铂(6 mg/kg) IP,两组在第一天给予单剂量顺铂(150 mg/kg或300 mg/kg OELE,从第5天开始,连续10天,另一组作为对照。结果与结论。结果表明,顺铂诱导的肾毒性表现为血清肌酐、血尿素氮(BUN)显著升高,肌酐清除率和钾水平显著降低,这与肾组织病理改变相一致。OELE显著改善顺铂的剂量依赖性肾毒性作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Ameliorative Effect of Olea europaea Leaf Extract on Cisplatin-Induced Nephrotoxicity in the Rat Model.

Background: Olea europaea leaf extract (OELE) has potential health benefits and protects against cytotoxicity. This study investigated the possible ameliorative effect of OELE on cisplatin-induced nephrotoxicity in rats.

Methods: Rats were assigned into six groups; two groups received 150 mg/kg or 300 mg/kg of OELE, one group received a single dose of cisplatin (6 mg/kg) IP on the first day of the experiment, two groups received a single dose of cisplatin 150 mg/kg or 300 mg/kg of OELE on the first day then starting from the fifth day for 10 consecutive days, and one group acted as a control. Results and Conclusion. The findings showed that cisplatin-induced nephrotoxicity was evidenced by a significant increase in serum creatinine blood urea nitrogen (BUN) and a significant decrease in estimated creatinine clearance and potassium level, which corresponded with the alterations in the histopathology of the renal tissue. OELE significantly ameliorated the nephrotoxic effects of cisplatin as dose-dependent.

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来源期刊
International Journal of Nephrology
International Journal of Nephrology UROLOGY & NEPHROLOGY-
CiteScore
3.40
自引率
4.80%
发文量
44
审稿时长
17 weeks
期刊介绍: International Journal of Nephrology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on the prevention, diagnosis, and management of kidney diseases and associated disorders. The journal welcomes submissions related to cell biology, developmental biology, genetics, immunology, pathology, pathophysiology of renal disease and progression, clinical nephrology, dialysis, and transplantation.
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