儿科人群中颈面部非结核分枝杆菌感染的治疗现状。

IF 1.9 4区 医学 Q2 OTORHINOLARYNGOLOGY Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2023-12-01 Epub Date: 2023-09-12 DOI:10.1097/MOO.0000000000000927
Keshav V Shah, Lazaro R Peraza, Joshua P Wiedermann
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引用次数: 0

摘要

综述目的:本综述的目的是分析和整合最近发表的文献,为儿科人群中非结核分枝杆菌性淋巴结炎(NTM-LAD)的诊断和治疗提供最新指南,并提出进一步研究的领域。最近的发现:NTM-LAD的诊断依赖于详细的临床病史、身体检查、实验室测试和成像技术。治疗策略差异很大,由于治愈率更高、美观效果改善和复发率更低,观察到向完全手术切除的转变。但是,必须考虑患者的具体因素。遗传因素的作用,如孟德尔对分枝杆菌病(MSMD)的易感性,正在得到越来越多的认识,并可能导致靶向治疗。摘要:尽管在NTM-LAD的理解和管理方面取得了进展,但在诊断成像的作用、最佳治疗参数、术后护理和监测策略等关键领域仍存在巨大差距。在这篇文章中,我们解释了我们使用最相关的循证医学进行NTM的方法,同时为未来的工作提供了方向。
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Current management of cervicofacial nontuberculous mycobacterial infections in the pediatric population.

Purpose of review: The purpose of this review is to analyze and consolidate recently published literature to provide updated guidelines on the diagnosis and management of nontuberculous mycobacterial lymphadenitis (NTM LAD) in the pediatric population and to suggest areas of further research.

Recent findings: Diagnosis of NTM LAD relies on a detailed clinical history, physical examination, laboratory tests, and imaging techniques. Treatment strategies vary widely, with a shift towards complete surgical excision being observed due to its higher cure rate, improved aesthetic outcomes, and lower recurrence rates. However, patient-specific factors must be considered. The role of genetic factors, such as Mendelian susceptibility to mycobacterial disease (MSMD), is being increasingly recognized and could lead to targeted therapies.

Summary: Despite strides in the understanding and management of NTM LAD, substantial gaps remain in key areas such as the role of diagnostic imaging, optimal treatment parameters, postoperative care, and surveillance strategies. In this article, we explain our approach to NTM using the most relevant evidence-based medicine while offering directions for future work.

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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
96
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Otolaryngology & Head and Neck Surgery is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With eleven disciplines published across the year – including maxillofacial surgery, head and neck oncology and speech therapy and rehabilitation – every issue also contains annotated references detailing the merits of the most important papers.
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